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Contact

Prof. Dr. Svante Pääbo

Director, Department of Genetics

Max Planck Institute for Evolutionary Anthropology

Deutscher Platz 6
04103 Leipzig

phone: +49 341 3550 - 500
fax: +49 341 3550 - 555

e-mail: paabo@[>>> Please remove the brackets! <<<]eva.mpg.de

A High Coverage Denisovan Genome

toothThe genome sequence of a Denisovan individual was generated from a small fragment of a finger bone discovered in Denisova Cave in southern Siberia in 2008.

Approximately 30-fold coverage of the genome was generated using the Illumina GAIIx sequencing platform.

This data is freely available without passwords.

Focussing on the "mappable genome" - the 1.86GB of unique sequence with  clear human-chimpanzee orthology  - we see 99.97% of bases covered at least 3x and 99.51% covered at least 10x.

Contamination with modern human DNA, estimated from both mitochondrial and nuclear genomes, is less than 1%.

Downloads

The Denisova Genome Consortium have released for public use the raw sequence data, alignments and genotype calls for the high-coverage genome sequence of a Denisovan individual, as well as the modern human sequences presented in the publication.

When using this genome data please cite the following publication:

Meyer M, Kircher M, Gansauge MT, Li H, Racimo F, Mallick S, Schraiber JG, Jay F, Prufer K, de Filippo C, Sudmant PH, Alkan C, Fu Q, Do R, Rohland N, Tandon A, Siebauer M, Green RE, Bryc K, Briggs AW, Stenzel U, Dabney J, Shendure J, Kitzman J, Hammer MF, Shunkov MV, Derevianko AP, Patterson N, Andres AM, Eichler EE, Slatkin M, Reich D, Kelso J, Paabo S: A High-Coverage Genome Sequence from an Archaic Denisovan Individual. Science. Aug 31 2012.

Provided here are the alignments using BWA to the human (hg19/GRCh37) and chimpanzee (panTro2) genomes.

Download data

The sequence, alignment  and genotype data is made available through:

Denisova CaveDenisova_Cave