Genetic Diversity and Selection
Aida Andrés

The main aim of the lab is to help establish the influence that natural selection has played in the evolution of humans and other primates, with special focus on the role of adaptation in the evolution of loci with a critical effect in phenotype. We combine comparative genomics with population genetics to identify targets of selection, and computational and experimental approaches to establish the functional consequences of their genetic variants.

Our work includes:

• Localizing signatures of natural selection in the genome, and confirming the influence of selection through detailed gene-by-gene analyses;
• Establishing the level of conservation of selective forces among populations and species; and
• Determining the role of such selective events, and demography, in the phenotypic variability of present-day populations.