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Department of Evolutionary Genetics

Max Planck Institute for Evolutionary Anthropology

Deutscher Platz 6
04103 Leipzig

phone: +49 341 3550 - 500

e-mail: mittag@[>>> Please remove the brackets! <<<]eva.mpg.de

Scientific articles

1 Jones, B.N., Lewis, R.V., Pääbo, S., Kojima, K., Kimura, S., and Stein, S.: Effects of flowrate and eluant composition on the high performance, liquid chromatography of proteins. J. Liq. Chrom. 3(9): 1373-1381 (1980).
2 Jones, B.N., Pääbo, S., and Stein, S.: Amino acid analysis and enzymatic sequence determination of peptides by an improved o-phtaldialdehyde precolumn labeling procedure. J. Liq. Chrom. 4(4): 565-586 (1981).
3 Pääbo, S., Lundqvist, G., Peterson, B., and Andersson, A.: Hormone content of pancreatic islets subjected to different in vitro and in vivo functional demands. Experentia 37: 1213-1214 (1981).
4 Kämpe, O., Bellgrau, D., Hammerling, U., Lind, P., Pääbo, S., Severinsson, L., Peterson, P.A.: Complex formation between class I transplantation antigens and a viral glycoprotein. J. Biol. Chem. 258: 10594-10598 (1983).
5 Pääbo, S., Weber, F., Kämpe, O., Schaffner, W., and Peterson, P.A.: Association between class I transplantation antigens and a viral membrane protein synthesized from a mammalian expression vector. Cell 33: 445-453 (1983).
6 Pääbo, S., Kämpe, O., Severinsson, L., Andersson, M., Fernandez, C., and Peterson, P.A.: The association between class I transplantation antigens and an adenovirus membrane protein. Prog. Allergy 36: 114-134 (1984).
7 Pääbo, S.: Über den Nachweis von DNA in altägyptischen Mumien. Das Altertum 30: 213-218 (1984). [pdf]
8 Pääbo, S.: Preservation of DNA in ancient Egyptian mummies. J. Archaeol. Sci. 12: 411-417 (1985).
9 Pääbo, S.: Molecular cloning of ancient Egyptian mummy DNA. Nature 314: 644-645 (1985). [pdf]
10 Andersson, M., Pääbo, S., Nilsson, T., and Peterson, P.A.: Impaired intracellular transport of class I MHC antigens as a possible means for adeno-viruses to evade immune surveillance. Cell 43: 215-222 (1985).
11 Pääbo, S., Weber, F., Nilsson, T., Schaffner, W., and Peterson, P.A.: Structural and functional dissection of an MHC class I antigen-binding adenovirus glycoprotein. EMBO J. 5: 1921-1927 (1986).
12 Pääbo, S., Nilsson, T., and Peterson, P.A.: Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of MHC class I antigens. Proc. Natl. Acad. Sci. USA 83: 9665-9669 (1986).
13 Pääbo, S.: Molecular genetic investigations of ancient human remains. Cold Spring Harbor Symp. Quant. Biol. LI: 441-446 (1986).
14 Pääbo, S.: Molecular genetic methods in archaeology - a prospect. Anthropol. Anzeiger 45: 9-17 (1987).
15 Andersson, L., Pääbo, S., and Rask, L.: Is allograft rejection a clue to the mechanism promoting MHC polymorphism? Immunol. Today 8: 206-209 (1987).
16 Pääbo, S., Bhat, B.H., Wold, W.S.M., and Peterson, P.A.: A short sequence in the COOH-terminus makes an adenovirus membrane glycoprotein a resident of the endoplasmic reticulum. Cell 50: 311-317 (1987).
17 Pääbo, S., and Wilson, A.C.: Polymerase chain reaction revels cloning artefacts. Nature 334: 387-388 (1988). [pdf]
18 Pääbo, S., Gifford, J.A., and Wilson, A.C.: Mitochondrial DNA sequences from a 7000-year-old brain. Nucl. Acids Res. 16(20): 9775-9787 (1988). [pdf]
19 Pääbo, S., Severinsson, L., Andersson, M., Martens, I., Nilsson, T., and Peterson, P.A.: Adenovirus proteins and MHC expression. Adv. Cancer Res. 52: 151-163 (1989).
20 Ljunggren, H.-G., Pääbo, S., Cochet, M., Kling, G., Kourilsky, P., and Kärre, K.: Molecular analysis of H-2-deficient lymphoma lines. Distinct defects in biosynthesis and association of MHC class I heavy chains and ß2- microglobulin observed in cells with increased sensitivity to NK cell lysis. J. Immunol. 142: 2911-2917 (1989).
21 Pääbo, S.: Ancient DNA; extraction, characterization, molecular cloning and enzymatic amplification. Proc. Natl. Acad. Sci. USA 86: 1939-1943 (1989). [pdf]
22 Kocher, T.D., Thomas, W.K., Meyer, A., Edwards, S.V., Pääbo, S., Villablanca, F.X., and Wilson, A.C.: Dynamics of mitochondrial DNA evolution in animals: Amplification and sequencing with conserved primers. Proc. Natl. Acad. Sci. USA 86, 6196-6200 (1989). [pdf]
23 Pääbo, S., Higuchi, R.G., and Wilson, A.C.: Ancient DNA and the poly-merase chain reaction: The emerging field of molecular archaeology (Minireview). J. Biol. Chem. 264: 9709-9712 (1989). [pdf]
24 Thomas, R.H., Schaffner, W., Wilson, A.C., and Pääbo, S.: DNA phylogeny of the extinct marsupial wolf. Nature 340: 465-467 (1989). [pdf]
25 Pääbo, S., Irwin, D.M., and Wilson, A.C.: DNA damage promotes jumping between templates during enzymatic amplification. J. Biol. Chem. 265, 4718-4721 (1990).
26 Thomas, W.K., Pääbo, S., Villablanca, F.X., and Wilson, A.C.: Spatial and temporal continuity of kangaroo rat populations shown by sequencing mitochondrial DNA from museum specimens. J. Mol. Evol. 31: 101-112 (1990).
27 Thomas, R.H., Pääbo, S., and Wilson, A.C.: Chance marsupial relationships. Nature 345, 393-394 (1990).
28 Pääbo, S., Thomas, W.K., Whitfield, K.M., Kumazawa, Y., and Wilson, A.C.: Rearrangements of mitochondrial transfer RNA genes in marsupials. J. Mol. Evol. 33: 426-430 (1991).
29 Ward, R.H., Frazier, B.L., Dew-Jager, K., and Pääbo, S.: Extensive mitochondrial diversity within a single Amerindian tribe. Proc. Natl. Acad. Sci. USA 88: 8720-8724 (1991).
30 Pääbo, S., and Wilson, A.C.: Miocene DNA sequences - A dream come true? Current Biol. 1: 45-46 (1991). [pdf]
31 Welsh, N., Pääbo, S., and Welsh, M.: Decreased mitochondrial gene expression in isolated islets of rats injected neonatally with streptozotocin. Diabetologia 34: 626-631 (1991).
32 Sidow, A., Wilson, A.C., and Pääbo, S.: Bacterial DNA in Clarkia fossils. Phil. Trans. R. Soc. B. 333: 429-433 (1991).
33 Pääbo, S.: Amplifying DNA from Archeological Remains: A Meeting Report. PCR Methods Applic. 1: 107-110 (1991).
34 Cooper, A., Mourer-Chauviré, C., Chambers, G.K., von Haeseler, A., Wilson, A.C., and Pääbo, S.: Independent origins of New Zealand moas and kiwis. Proc. Natl. Acad. Sci. USA 89: 8741-8744 (1992).
35 Pääbo, S., Wayne, R., and Thomas, R.: On the use of museum collections for molecular genetic studies. Ancient DNA Newsletter 1: 4-5 (1992).
36 Höss, M., Kohn, M., Pääbo, S., Knauer, F., and Schröder, W.: Excrement analysis by PCR. Nature 359: 199 (1992).
37 Goloubinoff, P., Pääbo, S., and Wilson, A.C.: Evolution of maize inferred from sequence diversitz of an Adh2 gene segment from archaeological specimens. Proc. Natl. Acad. Sci. USA 90: 1997-2001 (1993).
38 Ward, R.H., Redd, A., Valencia, D., Frazier, B., and Pääbo, S.: Genetic and linguistic differentiation in the Americas. Proc. Natl. Acad. Sci. USA 90: 10663-10667 (1993).
39 Janke, A. and Pääbo, S.: Editing of a tRNA anticodon in marsupial mitochondria changes its codon recognition. Nucl. Acids Res. 21: 1523-1525 (1993).
40 Schliewen, U., Fricke, H., Schartl, M., Epplen, J.T., and Pääbo, S.: Which home for coelacanth? Nature 363: 405 (1993).
41 Höss, M. and Pääbo, S.: DNA extraction from Pleistocene bones by a silica-based purification method. Nucl. Acids Res. 21: 3913-3914 (1993)
42 von Haeseler, A., Janke, A., and Pääbo, S.: Molecular Phylogenetics. Proc. Ger. Zool. Soc. 86.2: 119-129 (1993).
43 Pääbo, S.: Ancient DNA. Sci. Am. 269(5): 86-92 (1993).
44 Thomas, W.K. and Pääbo, S.: DNA Sequences from Old Tissue Remains. Meth. Enz. 224: 406-419 (1993).
45 Schliewen, U.K., Tautz, D., and Pääbo, S.: Sympatric speciation suggested by monophyly of crater lake cichlids. Nature 368: 629-632 (1994).
46 Janke, A., Feldmaier-Fuchs, G., Thomas, W.K., von Haesler, A., and Pääbo, S.: The marsupial mitochondrial genome and the evolution of placental mammals. Genetics 137: 243-256 (1994).
47 Handt, O., Richards, M., Trommsdorff, M., Kilger, C., Simanainen, J., Georgiev, O., Bauer, K., Stone, A., Hedges, R., Schaffner, W., Utermann, G., Sykes, B., and Pääbo, S.: Molecular genetic analyses of the Tyrolean Ice Man. Science 264: 1775-1778 (1994).
48 Höss, M., Pääbo, S., and Vereshchagin, N.K.: Mammoth DNA sequences. Nature 370: 333 (1994). [pdf]
49 Handt, O., Höss, M., Krings, M., and Pääbo, S.: Ancient DNA: methodological challenges. Experientia 50: 524-529 (1994).
50 Bada, J.L., Wang, X.S., Poinar, H.N., Pääbo, S., and Poinar, G.O.: Amino acid racemization in amber-entombed insects: Implications for DNA preservation. Geochimica et Cosmochimica Acta 58: 3131-3135 (1994).
51 Gemmell, N.J., Janke, A., Western, P.S., Watson, J.M., Pääbo, S., and Marshall Graves, J.A.: Cloning and characterization of the platypus mitochondrial genome. J. Mol. Evol. 39: 200-205 (1994).
52 Cao, Y., Adachi, J., Janke, A., Pääbo, S., and Hasegawa, M.: Phylogenetic relationships among eutherian orders estimated from inferred sequences of mitochondrial proteins: Instability of a tree based on a single gene. J. Mol. Evol. 39: 519-527 (1994).
53 Pult, I., Sajantila, A., Simanainen, J., Georgiev, O., Schaffner, W., and Pääbo, S.: Mitochondrial DNA sequences from Switzerland reveal striking homogeneity of European populations. Biol. Chem. Hoppe-Seyler 375: 837-840 (1994). [pdf]
54 Kohn, M., Knauer, F., Stoffella, A., Schröder, W., and Pääbo, S.: Conservation genetics of the European brown bear - a study using excremental PCR of nuclear and mitochondrial sequences. Mol. Ecol. 4: 95-103 (1995). [pdf]
55 Dörner, M. and Pääbo, S.: Nucleotide sequence of a marsupial LINE-1 element and the evolution of placental mammals. Mol. Biol. Evol. 12: 944-948 (1995).
56 Mörl, M., Dörner, M., and Pääbo, S.: C to U editing and modifications during the maturation of the mitochondrial tRNAAsp in marsupials. Nucl. Acids Res. 23: 3380-3384 (1995).
57 Yokobori, S.-I. and Pääbo, S.: Transfer RNA editing in land snail mitochondria. Proc. Natl. Acad. Sci. USA 92: 10432-10435 (1995).
58 Comas, D., Pääbo, S., and Bertranpetit, J.: Heteroplasmy in the control region of human mitochondrial DNA. Genome Res. 5: 89-90 (1995).
59 Zischler, H., Höss, M., Handt, O., von Haeseler, A., van der Kuyl, A.C., Goudsmit, J., and Pääbo, S.: Detecting dinosaur DNA. Science 268: 1192- 193 (1995).
60 Pääbo, S.: The Y chromosome and the origin of all of us (men). (Perspective) Science 268: 1141-1142 (1995). [pdf]
61 Sajantila, A., Lahermo, P., Anttinen, T., Lukka, M., Sistonen, P., Savontaus, M.-L., Aula, P., Beckman, L., Tranebjaerg, L., Gedde-Dahl, T., Issel-Tarver, L., DiRienzo, A., and Pääbo, S.: Genes and languages in Europe: An analysis of mitochondrial lineages. Genome Res. 5: 42-52 (1995). [pdf]
62 Yokobori, S.-I. and Pääbo, S.: tRNA editing in metazoans. Nature 377: 490 (1995).
63 Zischler, H., Geisert, H., von Haeseler, A., and Pääbo, S.: A nuclear "fossil" of the mitochondrial D-loop and the origin of modern humans. Nature 378: 489-492 (1995).
64 Sajantila, A. and Pääbo, S.: Language replacement in Scandinavia. Nature Genet. 11: 359-360 (1995). [pdf]
65 Petri, B., Neuweiler, G., and Pääbo, S.: Mitochondrial diversity and heteroplasmy in two European populations of the large mouse-eared bat, Myotis myotis. Symp. Zool. Soc. Lond. 67: 397-403 (1995).
66 Janke, A., Gemmell, N.J., Feldmaier-Fuchs, G., von Haeseler, and Pääbo, S.: The mitochondrial genome of a monotreme - the platypus (Ornithorhynchus anatinus). J. Mol. Evol. 42: 153-159 (1996).
67 Höss, M., Dilling, A., Currant, A., and Pääbo, S.: Molecular phylogeny of the extinct ground sloth Mylodon darwinii. Proc. Natl. Acad. Sci. USA 93: 181-185 (1996).
68 Stone, A.C., Milner, G.R., Pääbo, S., and Stoneking, M.: Sex determination of ancient human skeletons using DNA. Am. J. Phys. Anthropol. 99: 231-238 (1996). [pdf]
69 Höss, M., Jaruga, P., Zastawny, T.H., Dizdaroglu, M., and Pääbo, S.: DNA damage and DNA sequence retrieval from ancient tissues. Nucl. Acids Res. 24: 1304-1307 (1996). [pdf]
70 Tishkoff, S.A., Dietzsch, E., Speed, W., Pakstis, A.J., Kidd, J.R., Cheung, K., Bonne-Tamir, B., Santachiara-Benerecetti, A.S., Moral, P., Krings, M., Pääbo, S., Watson, E., Risch, N., Jenkins, T., and Kidd, K.K.: Global patterns of linkage disequilibrium at the CD4 locus and modern human origins. [pdf]
71 Thomas, R., Zischler, H., Pääbo, S., and Stoneking, M.: Novel mitochondrial DNA insertion polymorphism and its usefulness for human population studies. Human Biol. 68: 847-854 (1996).
72 Armour, J.A.L., Anttinen, T., May, C.A., Vega, E.E., Sajantila, A., Kidd, J.R., Kidd, K.K., Bertranpetit, J., Pääbo, S., and Jeffreys, A.J.: Minisatellite diversity supports a recent African origin for modern humans. Nature Genet. 13: 154-160 (1996). [pdf]
73 Handt, O., Krings, M., Ward, R.H., and Pääbo, S.: The retrieval of ancient human DNA sequences. Am. J. Hum. Genet. 59: 376-386 (1996).
74 Börner, G.V., and Pääbo, S.: Evolutionary fixation of RNA editing. Nature 383: 225 (1996).
75 Poinar, H.N., Höss, M., Bada, J.L., and Pääbo, S.: Amino acid racemization and the preservation of ancient DNA. Science 272: 864-866 (1996) [pdf]
76 von Haeseler, A., Sajantila, A., and Pääbo, S.: The genetical archaeology of the human genome. Nature Genet. 14: 135-140 (1996). [pdf]
77 Watson, E., Bauer, K., Aman, R., Weiss, G., von Haeseler, A., and Pääbo, S.: mtDNA sequence diversity in Africa. Am. J. Hum. Genet. 59: 437-444 (1996)
78 Sajantila, A., Salem, A.-H., Savolainen, P., Bauer, K., Gierig, C., and Pääbo, S.: Paternal and maternal DNA lineages reveal a bottleneck in the founding of the Finnish population. Proc. Natl. Acad. Sci. USA 93: 12035-12039 (1996).
79 Salem, A.-H., Badr, F.M., Gaballah, M.F., and Pääbo, S.: The genetics of traditional living: Y chromosomal and mitochondrial lineages in the Sinai Peninsula. Am. J. Hum. Genet. 59: 741-743 (1996).
80 Börner, G.V., Mörl, M., Janke, A., and Pääbo, S.: RNA editing changes the identity of a mitochondrial tRNA in marsupials. EMBO J. 15: 5949-5957 (1996).
81 Pääbo, S.: Mutational hot spots in the mitochondrial microcosm. Am. J. Hum. Genet. 59: 493-496 (1996).
82 Petri, B., von Haeseler, A., and Pääbo, S.: Extreme sequence heteroplasmy in bat mitochondrial DNA. Biol. Chem. 377: 661-667 (1996). [pdf]
83 Kilger, C., Krings, M., Poinar, H., and Pääbo, S.: "Colony sequencing": Direct sequencing of plasmid DNA from bacterial colonies. BioTechniques 22, 412-414 (1997).
84 Benes, V., Kilger, C., Voss, H., Pääbo, S., and Ansorge, W.: Direct primer walking on P1 plasmid DNA. BioTechniques 23: 98-100 (1997).
85 Yokobori, S.-I., and Pääbo, S.: Polyadenylation creates the discriminator nucleotide of chicken mitochondrial tRNATyr. J. Mol. Biol. 265: 95-99 (1997).
86 Petri, B., Pääbo, S., von Haeseler, A. and Tautz, D.: Paternity assessment and population subdivision in a natural population of the larger mouse-eared bat (Myotis myotis). Mol. Ecol. 6: 235-242 (1997).
87 Kilger, C., and Pääbo, S.: Direct exponential amplification and sequencing (DEXAS) of genomic DNA. Biol. Chem. 378: 99-105 (1997).
88 Kilger, C., and Pääbo, S.: Direct DNA sequence determination from total genomic DNA. Nucleic Acids Res. 25: 2032-2034 (1997).
89 Krings, M., Stone, A., Schmitz, R.W., Krainitzki, H., Stoneking, M., and Pääbo, S.: Neandertal DNA sequences and the origin of modern humans. Cell 90: 19-30 (1997). [pdf]
90 Laan, M., and Pääbo, S.: Demographic history and linkage disequilibrium in human populations. Nature Genetics 17: 435-438 (1997).[pdf]
91 Börner, G.V., Yokobori, S.-I., Mörl, M., Dörner, M., and Pääbo, S.: RNA editing in metazoan mitochondria: Staying fit without sex. FEBS Lett. 409: 320-324 (1997).
92 Cooper, A., Poinar, H.N., Pääbo, S., Radovcic, J., Debenath, A., Caparros, M., Barroso-Riuz, C., Bertranpetit, J., Nielsen-Marsh, C., Hedges, R.E.M., and Sykes, B.: Neandertal genetics. Science 277: 1021-1025 (1997)
93 Gravlund, P., Meldgaard, M., Pääbo, S., and Arctander, P.: Polyphyletic origin of the small-bodied, high-arctic subspecies of tundra reindeer (Rangifer tarandus). Mol. Phylogenet. Evol. 10: 151-159 (1998).
94 Castresana, J., Feldmaier-Fuchs, G., and Pääbo, S.: Codon reassignment and amino acid composition in hemichordate mitochondria. Proc. Natl. Acad. Sci. USA 95: 3703-3707 (1998).
95 Terwilliger, J.D., Zöllner, S., Laan, M., and Pääbo, S.: Mapping genes through the use of linkeage disequilibrium generated by genetic drift. Human Heredity 48: 138-154 (1998).
96 Allen, M., Engström, A.-S., Meyer, S., Handt, O., Saldeen, T., von Haeseler, A., Pääbo, S., and Gyllensten, U.: Mitochondrial DNA sequencing of shed hairs and saliva on robbery caps: sensitivity and matching probabilities. J. For. Sci. 43(3): 453-464 (1998).
97 Castresana, J., Feldmaier-Fuchs, G., Yokobori, S.-I., Satoh, N., and Pääbo, S.: The mitochondrial genome of the hemichordate Balanoglossus carnosus and the evolution of deuterostome mitochondria. Genetics 150(3): 1115-1123 (1998).
98 Laan, M., and Pääbo, S.: Mapping genes by drift-generated linkage disequilibrium. Am. J. Hum. Genet. 63: 654-656 (1998).
99 Poinar, H.N., Hofreiter, M., Spaulding, W.G., Martin, P.S., Stankiewicz, B.A., Bland, H., Evershed, R.P., Possnert, G., and Pääbo, S.: Molecular coproscopy: The dung and diet of the extinct ground sloth Nothrotheriops shastensis. Science 281: 402-406 (1998).
100 Cao, Y., Janke, A., Waddell, P.J., Westerman, M., Takenaka, O., Murata, S., Okada, N., Pääbo, S., and Hasegawa, M.: Conflict among individual mitochondrial proteins in resolving the phylogeny of eutherian orders. J. Mol. Evol. 47: 307-322 (1998).
101 Greenwood, A.D, and Pääbo, S.: Nuclear insertion sequences of mitochondrial DNA predominate in hair but not in blood of elephants. Mol. Ecol. 8: 133-137 (1999).
102 Krings, M., Salem, A.-H., Bauer, K., Geisert, H., Malek, A.K., Chaix, L., Simon, C., Welsby, D., Di Rienzo, A., Utermann, G., Sajantila, A., Pääbo, S., and Stoneking, M.: mtDNA analysis of Nile River Valley populations: a genetic corridor or a barrier to migration? Am. J. Hum. Genet. 64: 1166-1176 (1999).
103 Kaessmann, H., Heißig, F., von Haeseler, A., and Pääbo, S.: DNA sequence variation in a non-coding region of low recombination on the human X chromosome. Nature Genetics 22: 78-81 (1999).
104 Krings, M., Geisert, H., Schmitz, R.W., Krainitzki, H., and Pääbo, S.: DNA sequence of the mitochondrial hypervariable region II from the Neandertal type specimen. Proc. Natl. Acad. Sci. USA 96: 5581-5585 (1999).
105 Greenwood, A.D., Capelli, C., Possnert, G., and Pääbo, S.: Nuclear DNA sequences from Pleistocene megafauna. Mol. Biol. Evol. 16: 1466-1473 (1999). [pdf]
106 Pääbo, S.: Neolithic genetic engineering (News and Views). Nature 398: 194-195 (1999).
107 Vigilant, L., and Pääbo, S.: A chimpanzee millenium. Biol. Chem. 380: 1353-1354 (1999).
108 Kaessmann, H., Wiebe, V., and Pääbo, S.: Extensive nuclear DNA sequence diversity among chimpanzees. Science 286: 1159-1162 (1999).
109 Pääbo, S.: Human Evolution. Trends Genet. 15(12): M13-M16 (1999).
110 Yokobori, S.-I., Ueda, T., Feldmaier-Fuchs, G., Pääbo, S., Ueshima, R., Kondow, A., Nishikawa, K., and Watanabe, K.: Complete DNA sequence of the mitochondrial genome of the ascidian Halocynthia roretzi (Chordata, urochordata). Genetics 153: 1851-1862 (1999).
111 Erlandsson, R., Wilson, J.F., and Pääbo, S.: Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans. Mol. Biol. Evol. 17: 804-812 (2000). [pdf]
112 Börner, G.V., Zeviani, M., Tiranti, V., Carrara, F., Hoffmann, S., Gerbitz, K.D., Lochmüller, H., Pongratz, D., Klopstock, T., Melberg, A., Holme, E., and Pääbo, S.: Decreased aminoacylation of mutant tRNAs in MELAS but not in MERRF patients. Human Mol. Genet. 9: 467-475 (2000).
113 Pääbo, S.: Of bears, conservation genetics, and the value of time travel (Commentary). Proc. Natl. Acad. Sci. USA 97: 1320-1321 (2000). [pdf]
114 Di Benedetto, G., Nasidze, I.S., Stenico, M., Nigro, L., Krings, M., Lanzinger, M., Vigilant, L., Stoneking, M., Pääbo, S., and Barbujani, G.: Mitochondrial DNA sequences in prehistoric human remains from the Alps. Eur. J. Hum. Genet. 8: 669-677 (2000). [pdf]
115 Hofreiter, M., Poinar, H.N., Spaulding, W.G., Bauer, K., Martin, P.S., Possnert, G., and Pääbo, S.: A molecular analysis of ground sloth diet through the last glaciation. Molecular Ecology 9: 1975-1984 (2000).
116 Krings, M., Capelli, C., Tschentscher, F., Geisert, H., Meyer, S., von Haeseler, A., Grossschmidt, K., Possnert, G., Paunovic, M. and Pääbo, S.: A view of Neandertal genetic diversity. Nature Genetics 26: 144-146 (2000).
117 Ingman, M., Kaessmann, H., Pääbo, S. and Gyllensten, U.: Mitochondrial genome variation and the origin of modern humans. Nature 408: 708-713 (2000).
118 Motz, M., Pääbo, S. and Kilger, C.: Improved cycle sequencing of GC-rich templates by a combination of nucleotide analogs. BioTechniques 29: 268-270 (2000). [pdf]
119 Greenwood, A.D., Castresana, J., Feldmaier-Fuchs, G. and Pääbo, S.: A molecular phylogeny of two extinct sloths. Molecular Phylogenetics and Evolution 18: 94-103 (2001). [pdf]
120 Kaessmann, H., Wiebe, V., Weiss, G. and Pääbo, S.: Great ape DNA sequences reveal a reduced diversity and an expansion in humans. Nature Genetics 27: 155-156 (2001).
121 Pääbo, S.: The human genome and our view of ourselves. Science 291: 1219-1220 (2001).
122 Poinar, H.N., Kuch, M., Sobolik, K.D., Barnes, I., Stankiewicz, A.B., Kuder, T., Spaulding, W.G., Bryant, V.M., Cooper, A. and Pääbo, S.: A molecular analysis of dietary diversity for three archaic Native Americans. Proc. Natl. Acad. Sci. USA 98: 4317-4322 (2001).
123 Poinar, H., Kuch, M., and Pääbo, S.: Molecular Analyses of Oral Polio Vaccine Samples. Science 292: 743-744 (2001).
124 Hofreiter, M., Serre, D., Poinar, H.N., Kuch, M., and Pääbo, S.: Ancient DNA. Nature Reviews Genetics, 2: 353-360 (2001).
125 Dörner, M., Altmann, M., Pääbo, S., and Mörl, M.: Evidence for Import of a Lysyl-tRNA into Marsupial Mitochondria. Mol. Biol. Cell 12: 2688-2698 (2001).[pdf]
126 Hofreiter, M., Jaenicke, V., Serre, D., von Haeseler, A., and Pääbo, S.: DNA sequences from multiple amplifications reveal artifacts induced by cytosine deamination in ancient DNA. Nucleic Acids Research 29: 4793-4799 (2001).
127 Kaessmann, H., and Pääbo, S.: The genetical history of humans and the great apes. Journal of Internal Medicine 251: 1-18 (2002).
128 Kaessmann, H., Zöllner, S., Gustafsson, A., Wiebe, V., Laan, M., Lundeberg, J., Uhlén, M., and Pääbo, S.: Extensive linkage disequilibrium in small human populations in Eurasia. Submitted to American Journal of Human Genetics 70: 673-685 (2002).
129 Hofreiter, M., Capelli, C., Krings, M., Waits, L., Conard, N., Münzel, S., Rabeder, G., Nagel, D., Paunovic, M., Jambresic, G., Meyer, S., Weiss, G., and Pääbo, S.: Ancient DNA analyses reveal high mitochondrial DNA sequence diversity and parallel morphological evolution of late Pleistocene cave bears. Molecular Biology & Evolution 19(8): 1244-1250 (2002).
130 Ebersberger, I., Metzler, D., Schwarz, C., and Pääbo, S.: Genomewide comparison of DNA sequences between humans and chimpanzees. American Journal of Human Genetics 70: 1490-1497 (2002).
131 Enard, W., Khaitovich, P., Klose, J., Zöllner, S., Heissig, F., Giavalisco, P., Nieselt-Struwe, K., Muchmore, E., Varki, A., Ravid, R., Doxiadis, G.M., Bontrop, R.E., and Pääbo, S.: Intra- and interspecific variation in primate gene expression patterns. Science 296: 340-343 (2002).
132 Enard, W., Przeworski, M., Fisher, S.E., Lai, C.S.L., Wiebe, V., Kitano, T., Monaco, A.P., and Pääbo, S.: Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418: 869-872 (2002).
133 Chou, H., Hayakawa, T., Diaz, S., Krings, M., Indriati, E., Leakey, M., Pääbo, S., Satta, Y., Takahata, N., and Varki, A.: Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution. Proc. Natl. Acad. Sci. USA 99: 11736-11741 (2002).
134 Motz, M., Sagner, G., Pääbo, S., and Kilger, C.: Sequential DEXAS - A method for obtaining DNA sequences from genomic DNA and blood in one reaction. Nucl. Acids Res. 31: E121 (2003).
135 Schmitz, R.W., Serre, D., Bonani, G., Feine, S., Hillgruber, F., Krainitzki, H., Pääbo, S., and Smith, F.H.: The Neandertal type site revisited: Interdisciplinary investigations of skeletal remains from the Neander Valley, Germany. Proc. Natl. Acad. Sci. USA 99: 13342-13347 (2002). [pdf]
136 Hellmann, I., Zöllner, S., Enard, W., Ebersberger, I., Nickel, B., and Pääbo, S.: Selection on human genes as revealed by comparisons to chimpanzee cDNA. Genome Res. 13: 831-837 (2003).
137 Enard, W., Ebersberger, I., Fischer, A., Heissig, F., Hellmann, I., Höffner, B., Khaitovich, P., Kitano, T., Köhler, K., Metzler, D., Nickel, B., Przeworski, M., Schwarz, C., Nowick, K., Wiebe, V., Winkler, M., Zöllner, S., and Pääbo, S.: Functional genomics in the chimpanzee. In: Progress-Report 1999-2002. German Human Genome Project: 112-113 (2002).
138 Gilad, Y., Man, O., Pääbo, S., and Lancet, D.: Human specific loss of olfactory receptor genes. Proc. Natl. Acad. Sci. USA 100: 3324-3327 (2003).
139 Pääbo, S.: The mosaic that is our genome. Nature 421: 409-412 (2003).
140 Gilad, Y., Bustamente, C.D., Lancet, D., and Pääbo, S.: Natural selection on the olfactory gene family in humans and chimpanzees. Am. J. Hum. Genet. 73: 489-501 (2003).
141 Hellmann, I., Ebersberger, I., Ptak, S., Pääbo, S., and Przeworski, M.: A neutral explanation for the correlation between diversity levels and recombination rates in humans. Am. J. Hum. Genet. 72: 1527-35 (2003).
142 Otte, K., Kranz, H., Kober, I., Thompson, P., Hoefer, M., Haubold, B., Remmel, B., Voss, H., Kaiser, C., Albers, M., Cheruvallath, Z., Jackson, D., Casari, G., Koegl, M., Paabo, S., Mous, J., Kremoser, C., and Deuschle, U.: Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol Cell Biol. 23: 864-72 (2003). [pdf]
143 Kitano, T., Schwarz, C., Nickel, B., and Pääbo, S.: Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees. Mol. Biol. Evol. 20: 1281-1289 (2003).
144 Poinar, H., Kuch, M., McDonald, G., Martin, P., and Pääbo, S.: Nuclear Gene Sequence from a Late Pleistocene Sloth Coprolite. Current Biol. 13: 1150-1152 (2003). [pdf]
145 Jaenicke-Després, V., Buckler, E., Smith, B. D., Gilbert, M.T.P., Cooper, A., Doebley, J., and Pääbo, S.: Early allelic selection in maize as revealed by ancient DNA. Science 302: 1206-1208 (2003).
146 Thalmann, O., Hebler, J., Poinar, H.N., Pääbo, S., and Vigilant, L.: Unreliable mtDNA data due to nuclear insertions: a cautionary tale from analysis of humans and other great apes. Molecular Ecology 13: 321-335 (2004). [pdf]
147 Serre, D., Langaney, A., Chech, M., Teschler-Nicola, M., Paunovic, M., Mennecier, P., Hofreiter, M., Possnert, G, and Pääbo, S.: No evidence of Neandertal mtDNA contribution to early modern humans. PLoS Biology 2: 313-317 (2004). [pdf]
148  Hofreiter, M., Rabeder, G., Jaenicke, V., Withalm, G., Nagel, D., Paunovic, M., Jambresic, G., and Pääbo, S.: Evidence for reproductive isolation between cave bear populations. Current Biology 14: 40-43 (2004). [pdf
149  Khaitovich, P., Mützel, B., She, X., Lachmann, M., Hellmann, I., Dietzsch, J., Steigele, S., Do, H.-H., Weiss, G., Enard, W., Heissig, F., Arendt, T., Nieselt-Struwe, K., Eichler, E.E., and Pääbo, S.: Regional patterns of gene expression in human and chimpanzee brains. Genome Research 14: 1462-1473 (2004). [pdf]
150  Fischer, A., Wiebe, V., Pääbo, S., and Przeworski, M: Evidence for a complex demographic history of chimpanzees. Mol. Biol. Evol. 21: 799-808 (2004). [pdf]
151 Ptak, S.E., Roeder, A.D., Stephens, M., Gilad, Y., Pääbo, S., and Przeworski, M.: Absence of the TAP2 human recombination hotspot in chimpanzees. PLoS Biology 2: 849-855 (2004). [pdf]
152 Enard, W., Fassbender, A., Model, F., Adorján, P., Pääbo, S., and Olek, A.: Differences in DNA methylation patterns between humans and chimpanzees. Current Biol. 14: R148-149 (2004). [pdf]
153 Enard, W., and Pääbo, S.: Comparative primate genomics. Ann. Rev. Genomics Hum. Genet. 5: 351-78 (2004). [pdf]
154 Gilad, Y., Wiebe, V., Przeworski, M., Lancet, D., and Pääbo, S.: Loss of olfactory recepter genes coincides with the acquisition of full trichromatic Vision in Primates. PLoS Biology 2: 120-125 (2004). Authorship retracted (see PLoS Biol 5(6): e148 doi:10.1371/journal.pbio.0050148)
155 Serre, D., Hofreiter, M., and Pääbo, S.: Mutations induced by ancient DNA extracts? Letter. Mol. Biol. Evol. 21: 1463-1467 (2004). [pdf]
156 Khaitovich, P., Weiss, G., Lachmann, M., Hellmann, I., Enard, W., Muetzel, B., Wirkner, U., Ansorge, W., and Pääbo, S.: A neutral model of transcriptome evolution. PLoS Biology 2: 682-689 (2004). [pdf]
157 Serre, D., and Pääbo, S.: Evidence for gradients of human genetic diversity within and among continents. Genome Research 14: 1679-1685 (2004). [pdf]
158 The International Chimpanzee Chromosome 22 Consortium: Watanabe, H., Fujiyama, A., Hattori, M., Taylor, T.D., Toyoda, A., Kuroki, Y., Noguchi, H., BenKahla, A., Lehrach, H., Sudbrak, R., Kube, M., Taenzer, S., Galgoczy, P., Platzer, M., Scharfe, M., Nordsiek, G., Blöcker, H., Hellmann, I., Khaitovich, P., Pääbo, S., Reinhardt, R., Zheng, H.-J., Zhang, X.-L., Zhu, G.-F., Wang, B.-F., Fu, G., Ren, S.-X., Zhao, G.-P., Chen, Z., Lee, Y.-S., Cheong, J.-E., Choi, S.-H., Wu, K.-M., Liu, T.-T., Hsiao, K.-J., Tsai, S.-F., Kim, C.-G., Oota, S., Kitano, T., Kohara, Y., Saitou, N., Park, H.-S., Wang, S.-Y., Yaspo, M.-L., and Sakaki, Y.: DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature 429: 382-388 (2004). [pdf]
159 Hofreiter, M., Serre, D., Rohland, N., Rabeder, G., Nagel, D., Conard, N., Münzel, S., and Pääbo, S.: Lack of phylogeography in European mammals before the last glaciation. Proc. Natl. Acad. Sci. USA 101: 12963-68 (2004). [pdf]
160 Pääbo, S., Poinar, H., Serre, D., Jaenicke-Després, V., Hebler, J., Rohland, N., Kuch, M., Krause, J., Vigilant, L., and Hofreiter, M.: Genetic analyses from ancient DNA. Ann. Rev. Genetics 38: 645-79 (2004). [pdf]
161 Fischer, A., Gilad, Y., Man, O., and Pääbo, S.: Evolution of bitter taste receptors in humans and apes. Mol. Biol. Evol. 22: 432-436 (2005). [pdf]
162 Yohn, C.T., Jiang, Z., McGrath, S.D., Hayden, K.E., Khaitovich, P., Johnson, M.E., Eichler, M.Y., McPherson, J.D., Zhao, S., Pääbo, S., and Eichler, E.E.: Lineage-specific expansions of retroviral insertions within the genomes of African great-apes but not humans and orangutans. PLoS Biology 3: 577-587 (2005) [pdf]
163 Khaitovich, P., Hellmann, I., Enard, W., Nowick, K., Leinweber, M., Franz, H., Weiss, G., Lachmann, M., and Pääbo, S.: Parallel patterns of evolution in genomes and transcriptomes of humans and chimpanzees. Science 209: 1850-1854 (2005). [online article]
164 Laan, M., Wiebe, V., Khusnutdinova, E., Remm, M., and Pääbo, S.: X-chromosome as a marker for pupulation history: linkage disequlibrium and haplotype study in Eurasian populations. Eur. J. Hum. Genet. 13: 452-462 (2005). [pdf]
165 Ptak, S.E., Hinds, D.A., Koehler, K., Nickel, B., Patil, N., Ballinger, D.G., Przeworski, M., Frazer, K.A., and Pääbo, S.: Fine-scale recombination patterns differ between chimpanzees and humans. Nature Genetics 37: 429-434 (2005). [pdf]
166 Hellmann, I., Prüfer, K., Ji, H., Zody, M.C., Pääbo, S., and Ptak, S.E.: Why do human diversity levels vary at a megabase scale? Genome Research 15: 1222-1231 (2005). [pdf]
167 Rohland, N., Pollack, J., Nagel, D., Beauval, C., Mareille, B., Pääbo, S., and Hofreiter, M.: The population history of extant and extinct hyenas. Mol. Biol. Evol. 22: 2435-43 (2005). [pdf]
168 Heissig, F., Krause, J. Bryk, J., Khaitovich, P, Enard, W., and Pääbo, S.: Functional analysis of human and chimpanzee promoters. Genome Biology 6: R57 (2005). [pdf]
169 Beauval, C., Maureille, B., Lacrampe-Cuyaubère, F., Serre, D., Peressinotto, D., Bordes, J.-G., Cochard, D., Couchoud, I., Dubrasquet, D., Laroulandie, V., Lenoble, A., Mallye, J.-B., Pasty, S., Primault, J., Rohland, N., Pääbo, S., and Trinkaus, E.: A late Neandertal femur from Les Rochers-de-Villeneuve, France. PNAS 102: 7085-7090 (2005). [pdf]
170 Khaitovich, P., Pääbo, S., and Weiss, G.: Toward a neutral evolutionary model of gene expression. Genetics 170: 929-939 (2005). [pdf]
171 Krause, J., Dear, P.H., Pollack, J., Slatkin, M., Spriggs, H., Barnes, I., Lister, A., Ebersberger, I., Pääbo, S., and Hofreiter, M.: Multiplex amplification of the mammoth mitochondrial genome and the evolution of elephantidae. Nature: doi:10.1038/nature04432 (2005). [pdf]
172 Noonan, J. P., Hofreiter, M., Smith, D., Priest, J.R., Rohland, N., Rabeder, G., Krause, J., Detter, J.C., Pääbo, S., and Rubin, E.M.: Genomic sequencing of pleistocene cave bears. Science 309: 597-600 (2005). [pdf]
173 Franz, H., Ullmann, C., Becker, A., Ryan, M., Bahn, S., Arendt, T., Simon, M., Pääbo, S., and Khaitovich, P.: Systematic analysis of gene expression in human brains before and after death. Genome Biology 6: R112 (doi:10.1186/gb-2005-6-13-r112) (2005). [pdf]
174 Fraser, H.B., Khaitovich, P., Plotkin, J.B., Pääbo, S., and Eisen, M.B.: Aging and gene expression in the primate brain. PLoS Biology 3: e274: 1653-1661 (2005). [pdf]
175 Römpler, H., Schulz, A., Pitra, C., Coop, G., Przeworski, M., Pääbo, S., and Schöneberg, T.: The rise and fall of the chemoattractant receptor GPR33. J. Biol. Chem. 280: 31068-31075 (2005). [pdf]
176 The Chimpanzee Sequencing and Analysis Consortium: Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 437: 69-87 (2005). [pdf]
177 Cheng, Z., Ventura, M., She, X., Khaitovich, P., Graves, T., Osoegawa, K., Church, D., DeJong, P., Wilson, R.K., Pääbo, S., Rocchi, M., and Eichler, E.E.: A genome-wide comparison of recent chimpanzee and human segmental duplications. Nature 437: 88-93 (2005). [pdf]
178 Khaitovich, P., Tang, K., Franz, H., Kelso, J., Hellmann, I., Enard, W., Lachmann, M., and Pääbo, S.: Positive selection on gene expression in the human brain. Current Biology 16: R356-58 (2006). [pdf]
179 Somel, M., Khaitovich, P., Bahn, S., Pääbo, S., and Lachmann, M.: Gene expression becomes heterogeneous with age. Current Biology 16: R359-60 (2006). [pdf]
180 Fish, J.L., Kosodo, Y., Enard, W., Pääbo, S., and Huttner, W.B.: Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proc. Natl. Acad. Sci. USA 103: 10438-10443 (2006). [pdf]
181 Prüfer, K., Muetzel, B., Do, H., Weiss, G., Khaitovich, P., Rahm, E., Pääbo, S., Lachmann, M., and Enard, W.: FUNC: a package for detecting significant associations between gene sets and ontological annotations. BMC Bioinformatics 8, doi:10.1186/1471-2105-8-41 (2007). [pdf]
182 Hublin, J.-J., and Pääbo, S.: Neandertals. Current Biology 16: R113-14 (2006). [pdf]
183 Khaitovich, P., Enard, W., Lachmann, M., and Pääbo, S.: Evolution of primate gene expression. Nature Reviews Genetics 7: 693-702 (2006). [pdf]
184 Fischer, A., Pollack, J., Thalmann, O., Nickel, B., and Pääbo, S.: Demographic history and genetic differentiation in apes. Current Biology 16: 1133-38 (2006). [pdf]
185 Stiller, M., Green, R.E., Ronan, M., Simons, J.F., Du, L., He, W., Egholm, M., Rothberg, J., Keats, S.G., Ovodov, N.D., Antipina, E.E., Baryshnikov, G.F., Kuzmin, Y.V., Vasilevski, A.A., Wuenschell, G.E., Termini, J., Hofreiter, M., Jaenicke-Després, V., and Pääbo, S.: Patterns of nucleotide misincorporations during enzymatic amplification and direct large-scale sequencing of ancient DNA. PNAS 103: 13578-84 (2006). [pdf]
186 Noonan, J.P., Coop, G., Kudaravalli, S., Smith, D., Krause, J., Alessi, J., Chen, F., Platt, D., Pääbo, S., Pritchard, J.K., and Rubin, E.M.: Sequencing and analysis of Neanderthal genomic DNA. Science 314: 1113-18 (2006). [pdf]
187 Green, R.E., Krause, J., Ptak, S.E., Briggs, A.W., Ronan, M.T., Simons, J.F., Du, L., Egholm, M., Rothberg, J.M., Paunovic, M., and Pääbo, S.: Analysis of one million base pairs of Neanderthal DNA. Nature 444: 330-36 (2006). [pdf]
188 Khaitovich, P., Kelso, J., Franz, H., Visagie, J., Giger, T., Joerchel, S., Petzold, E., Green, R.E., Lachmann, M., and Pääbo, S.: Functionality of intergenetic transcription: An evolutionary comparison. PLoS Genetics 2: 1590-1598 (2006). [pdf]
189 Prabhakar, S., Noonan, J.P., Pääbo, S., and Rubin, E.M.: Accelerated evolution of conserved noncoding sequences in humans. Science 314: 786 (2006). [pdf]
190 Stroud, J.C., Wu, Y., Bates, D.L., Han, A., Nowick, K., Pääbo, S., Tong, H., and Chen, L.: Structure of the forkhead domain of FOXP2 bound to DNA. Structure 14: 159-166 (2006). [pdf]
191 Lalueza-Fox, C., Krause, J., Caramelli, D., Catalano, G., Milani, L., Sampietro, M.L., Calafell, F., Martinez-Maza, C., Bastir, M., Garcia-Tabernero, A., de la Rasilla, M., Fortea, J., Pääbo, S., Bertranpetit, J., and Rosas, A.: Mitochondrial DNA of an Iberian Neandertal suggests a population affinity with other European Neandertals. Curr. Biol. 16: R629-30 (2006). [pdf]
192 Hofreiter, M., Münzel, S., Conard, N.J., Pollack, J., Slatkin, M., Weiss, G., and Pääbo, S.: Sudden replacement of cave bear mitochondrial DNA in the late Pleistocene. Current Biology 17: R122-23 (2007). [pdf]
193 Thalmann, O., Fischer, A., Lankester, F., Pääbo, S., and Vigilant, L.: The complex evolutionary history of gorillas: Insights from genomic data. Mol. Biol. Evol. 24: 146-158 (2007). [pdf]
194 Chen, H., Green, R.E., Pääbo, S., and Slatkin, M.: The joint allele-frequency spectrum in closely related species. Genetics: doi: 0.1534/genetics.107.070730 (2007). [pdf]
195 Weber, M., Hellmann, I., Stadler, M.B., Ramos, L., Pääbo, S., Rebhan, M., and Schübeler, D.: Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome. Nature Genet. 39: 457-466 (2007) . [pdf]
196 Krause, J., Orlando, L., Serre, D., Viola, B., Prüfer, K., Richards, M.P., Hublin, J.-J., Hänni, C., Derevianko, A.P., and Pääbo, S.: Neanderthals in central Asia and Siberia. Nature 449: 902-904 (2007). [pdf]
197 Briggs, A.W., Stenzel, U., Johnson, P.L.F., Green, R.E., Kelso, J., Prüfer, K., Meyer, M., Krause, J., Ronan, M.T., Lachmann, M., and Pääbo, S.: Patterns of damage in genomic DNA sequences from a Neandertal. Proc. Natl. Acad. Sci. USA, 104: 14616-21 (2007). [pdf]
198 d'Abbadie, M., Hofreiter, M., Vaisman, A., Loakes, D., Gasparutto, D., Cadet, J., Woodgate, R., Pääbo, S., and Holliger P.: Molecular breeding of polymerases for amplification of ancient DNA. Nature Biotechnology 25: 939-43 (2007). [pdf]
199 Krause, J., Lalueza-Fox, C., Orlando, L., Enard, W., Green, R.E., Burbano, H.A., Hublin, J.-J., Bertranpetit, J., Hänni, C., Fortea, J., de la Rasilla, M., Rosas, A., and Pääbo, S.; The derived FOXP2 variant of modern humans was shared with Neandertals. Current Biology 17, doi:10.1016/j.cub.2007.10.008 (2007). [pdf]
200 Fu, N., Drinnenberg, I., Kelso, J., Wu, J.R., Pääbo, S., Zeng, R., and Khaitovich, P.: Comparison of protein and mRNA expression evolution in humans and chimpanzees. PLoS One 2 (2): e216 (2007). [pdf]
201 Albert, F.W., Shchepina, O., Winter, C., Roempler, H., Teupser, D., Palme, R., Ceglarek, U., Kratzsch, J., Sohr, R., Trut, L.N., Thiery, J., Morgenstern, R., Plyusnina, I.Z., Schoeneberg, T., and Pääbo, S.: Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans. Hormones and Behavior 53: 413-421 (2008). [pdf]
202 Meyer, M., Briggs, A. W., Maricic, T., Höber, B., Höffner, B., Krause, J., Weihmann, A., Pääbo, S., and Hofreiter, M.: From micrograms to picograms: quantitative PCR reduces the material demands of high-throughput sequencing. Nucleic Acids Research 36: e5 (2008). [pdf]
203 Somel, M., Creely, H., Franz, H., Mueller, U., Lachmann, M., Khaitovich, P., and Pääbo, S.: Human and chimpanzee gene expression differences replicated in mice fed different diets. PLoS One 3 (1): e1504 (2008). [pdf]
204 Groszer, M., Keays, D.A., Deacon, R.M.J., de Bono, J.P., Prasad-Mulcare, S., Gaub, S., Baum, M.G., French, C.A., Nicod, J., Coventry, J.A., Enard, W., Fray, W., Brown, S.D.M., Nolan, P.M., Pääbo, S., Channon, K.M., Costa, R.M., Eilers, J., Ehret, G., Rawlins, J.N.P., and Fisher, S.E.: Impaired motor learning and synaptic plasticity in mice carrying a point mutation implicated in human speech deficits. Current Biology. Hormones and Behavior 53: 413-421 (2008). [pdf]
205 Hublin, J.-J., Pääbo, S., et al.: Suggested guidelines for invasive sampling of hominid remains. Journal of Human Evolution 55: 756-757 (2008).[pdf]
206 Green, R.E., Malaspinas, A.-S., Krause, J., Briggs, A.W., Johnson, P.L.F., Uhler, C., Meyer, M., Good, J.M., Maricic, T., Stenzel, U., Prüfer, K., Siebauer, M., Burbano, H.A., Ronan, M., Rothberg, J.M., Egholm, M., Rudan, P., Brajković, D., Kućan, Ž., Gušić, I., Wikström, M., Laakkonen, L., Kelso, J., Slatkin, M., and Pääbo, S.: A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing. Cell 134: 416-426 (2008). [pdf]
207 Krause, J., Unger, T., Noçon, A., Malaspinas, A.-S., Kolokotronis, S.-O., Stiller, M., Soibelzon, L., Spriggs, H., Dear, P.H., Briggs, A.W., Bray, S.C.E., O'Brien, S.J., Rabeder, G., Matheus, P., Cooper, A., Slatkin, M., Pääbo, S., and Hofreiter, M.: Mitochondrial genomes reveal an explosive radiation of extinct and extant bears near the Miocene-Pliocene boundary. BMC Evolutionary Biology 8: 220, doi:10.1186/1471-2148-8-220 (2008). [pdf]
208 Khaitovich, P., Lockstone, H.E., Wayland, M.T., Tsang, T.M., Jayatilaka, S.D., Guo, A.J., Zhou, J., Somel, M., Harris, L.W., Holmes, E., Pääbo, S., and Bahn, S.: Metabolic changes in schizophrenia and human brain evolution. Genome Biology 9: R124, doi:10.1186/gb-2008-9-8-r124 (2008). [pdf]
209 Farkas, L.M., Haffner, C., Giger, T., Khaitovich, P., Nowick, K., Birchmeier, C., Pääbo, S., and Huttner, W.B.: Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex. Neuron 60: 40-55 (2008). [pdf]
210 Maricic, T., and Pääbo, S.: Optimization of 454 sequencing library preparation from small amounts of DNA permits sequence determination of both DNA strands. BioTechniques 46: 51-57 (2009). [pdf]
211 Somel, M., Franz, H., Yan, Z., Lorenc, A., Guo, S., Giger, T., Kelso, J., Nickel, B., Dannemann, M., Bahn, S., Webster, M.J., Weichert, C.S., Lachmann, M., Pääbo, S., and Khaitovich, P.: Transcriptional neoteny in the human brain. PNAS 106: 5743-48 (2009). [pdf]
212 Albert, F.W., Carlborg, Ö., Plyusnina, I., Besnier, F., Hedwig, D., Lautenschläger, S., Lorenz, D., McIntosh, J., Neumann, C., Richter, H., Zeising, C., Kozhemyakina, R., Shchepina, O., Kratzsch, J., Trut, L., Teupser, D., Thiery, J., Schöneberg, T., Andersson, L., and Pääbo, S.:Genetic architecture of tameness in a rat model of animal domestication. Genetics 182: 541-554 (2009). [pdf]
213 Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S.M., Blass, T., Somel, M., Brückner, M.K., Schreiweis, C., Winter, C., Sohr, R., Becker, L., Wiebe, V., Nickel, B., Giger, T., Müller, U., Groszer, M., Adler, T., Aguilar, A., Bolle, I., Calzada-Wack, J., Dalke, C., Ehrhardt, N., Favor, J., Fuchs, H., Gailus-Durner, V., Hans, W., Hölzlwimmer, G., Javaheri, A., Kalaydjiev, S., Kallnik, M., Kling, E., Kunder, S., Moßbrugger, I., Naton, B., Racz, I., Rathkolb, B., Rozman, J., Schrewe, A., Busch, D., Graw, J., Ivandic, B., Klingenspor, M., Klopstock, T., Ollert, M., Quintanilla-Martinez, L., Schulz, H., Wolf, E., Wurst, W., Zimmer, A., Fisher, S.E., Morgenstern, R., Arendt, T., Hrabé de Angelis, M., Fischer, J., Schwarz, J., and S. Pääbo: A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 137: 961-71 (2009). [pdf]
214 Ptak, S., Enard, W., Wiebe, V., Hellmann, I., Krause, J., Lachmann, M., and Pääbo, S.: Linkage disequilibrium extends across putative selected sites in FOXP2. Mol. Biol. Evol., doi:10.1093/molbev/msp143 (2009). [pdf]
215 Briggs, A., Good, J.M., Green, R.E., Krause, J., Maricic, T., Stenzel, U., Lalueza-Fox, C., Rudan, P., Brajkovic, D., Kucan, Ž., Gušic, I., Schmitz, R., Doronichev, V.B., Golovanova, L.V., de la Rasilla, M., Fortea, J., Rosas, A., and Pääbo, S.: Targeted retrieval and analysis of five Neandertal mtDNA genomes. Science 325: 318-321 (2009). [pdf]
216 Green, R.E., Briggs, A.W., Krause, J., Prüfer, K., Burbano, H.A., Siebauer, M., Lachmann, M., and Pääbo, S.: The Neandertal genome and ancient DNA authenticity. EMBO Journal, 28: 2494-2502 (2009). [pdf]
217 Briggs, A.W., Good, J.M., Green, R.E., Krause, J., Maricic, T., Stenzel, U., and Pääbo, S.: Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources. JoVE. 31.http://www.jove.com/index/details.stp?id=1573, doi: 10.3791/1573 (2009). [pdf]
218 Weickert, C.S., Elashoff, M., Richards, A.B., Sinclair, D., Bahn, S., Pääbo, S., Khaitovich, P., and Webster, M.: Transcriptome analysis of male-female differences in prefrontal cortical development. Molecular Psychiatry 14: 558-561 (2009). [pdf]
219 Briggs, A.W., Stenzel, U., Meyer, M., Krause, J., Kircher, M., and Pääbo, S.: Removal of deaminated cytosines and detection of in vivo methylation in ancient DNA. Nucleic Acids Research 38 (6) e87 (2010). [pdf]
220 Krause, J., Briggs, A.W., Kircher, M., Maricic, T., Zwyns, N., Derevianko, A.P., and Pääbo, S.: A complete mtDNA genome of an early modern human from Kostenki, Russia. Current Biology 20: 231-236 (2010). [pdf]
221 Krause, J., Fu, Q., Good, J.M., Viola, B., Shunkov, M.V., Derevianko, A.P., and Pääbo, S.: The complete mtDNA genome of an unknown hominin from Southern Siberia. Nature 464: 894-897 (2010). [pdf]
222 Prüfer, K., Stenzel, U., Hofreiter, M., Pääbo, S., Kelso, J., and Green, R.E.: Computational challenges in the analysis of ancient DNA. Genome Biology 11: R47 (2010). [pdf]
223 Burbano, H.A., Hodges, E., Green, R.E., Briggs, A.W., Krause, J., Meyer, M., Good, J.M., Maricic, T., Johnson, P.L.F., Xuan, Z., Rooks, M., Bhattacharjee, A., Brizuela, L., Albert, F.W., de la Rasilla, M., Fortea, J., Rosas, A., Lachmann, M., Hannon, G.J., and Pääbo, S.: Targeted investigation of the Neandertal genome by array-based sequence capture. Science 328: 723-25 (2010). [pdf]
224 Addis, L., Friederici, A.D., Kotz, S.A., Sabisch, B., Barry, J., Richter, N., Ludwig, A.A., Rübsamen, R., Albert, F.W., Pääbo, S., Newbury, D.F., and Monaco, A.P.: A locus for an auditory processing deficit and language impairment in an extended pedigree maps to 12p13.31-q14.3. Genes, Brain & Behavior 9: 545-61 (2010). [pdf]
225 Green, R.E., Krause, J., Briggs, A.W., Maricic, T., Stenzel, U., Kircher, M., Patterson, N., Li, H., Zhai, W., Fritz, M.H-Y., Hansen, N.F., Durand, E.Y., Malaspinas, A.-S., Jensen, J.D., Marques-Bonet, T., Alkan, C., Prüfer, K., Meyer, M., Burbano, H.A., Good, J.M., Schultz, R., Aximu-Petri, A., Butthof, A., Höber, B., Höffner, B., Siegemund, M., Weihmann, A., Nusbaum, C., Lander, E.S., Russ, C., Novod, N., Affourtit, J., Egholm, M., Verna, C., Rudan, P., Brajković, D., Kućan, Ž., Gušić, I., Doronichev, V.B., Golovanova, L.V., Lalueza-Fox, C., de la Rasilla, M., Fortea, J., Rosas, A., Schmitz, R.W., Johnson, P.L.F., Eichler, E.E., Falush, D., Birney, E., Mullikin, J.C., Slatkin, M., Nielsen, R., Kelso, J., Lachmann, M., Reich, D., and Pääbo, S.:A draft sequence of the Neandertal genome. Science 328: 710-22 (2010). [pdf]
226 Giger, T., Khaitovich, P., Somel, M., Lorenc, A., Lizano, E., Harris, L., Ryan, M., Lan, M., Wayland, M., Bahn, S., and Pääbo, S.: Evolution of neuronal and endothelial transcriptomes in primates. Genome Biology and Evolution 2: 284-292 (2010). [pdf]
227 Xu, A.G., He, L., Li, Z., Xu, Y., Li, M., Fu, X., Yan, Z., Yuan, Y., Menzel, C., Li, N., Somel, M., Hu, H., Chen, W., Pääbo, S., and Khaitovich, P.: Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-seq. PLoS Computational Biology 6 (7): e1000843 (2010). [pdf]
228 Pulvers, J.N., Bryk, J., Fish, J.L., Wilsch-Bräuninger, M., Arai, Y., Schreier, D., Naumann, R., Helppi, J., Habermann, B., Vogt, J., Nitsch, R., Tóth, A., Enard, W., Pääbo, S., and Huttner, W.B.: Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. PNAS 107: 16595-16600 (2010). [pdf]
229 Maricic, T., Whitten, M., and Pääbo, S.: Multiplexed DNA sequence capture of mitochondrial genomes using PCR products. PLoS ONE 5 (11), e14004 (2010). [pdf]
230 Reich, D., Green, R.E., Kircher, M., Krause, J., Patterson, N., Durand, E.Y., Viola, B., Briggs, A.W., Stenzel, U., Johnson, P.L.F., Maricic, T., Good, J.M., Marques-Bonet, T., Alkan, C., Fu, Q., Mallick, S., Li, H., Meyer, M., Eichler, E.E., Stoneking, M., Richards, M., Talamo, S., Shunkov, M.V., Derevianko, A.P., Hublin, J.-J., Kelso, J., Slatkin, M., and Pääbo, S.: Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature 468, 1053-1060 (2010). [pdf]
231 Gralle, M., Schäfer, I., Seibel, P., and Pääbo, S.: A functional test of Neandertal and modern human mitochondrial targeting sequences. Biochem. Biophys. Res. Comm. 402: 747-749 (2010). [pdf]
232 Reimers-Kipping, S., Hevers, W., Pääbo, S., and Enard, W.: Humanized Foxp2 specifically affects cortico-basal ganglia circuits. Neuroscience 175: 75-84. (2011). [pdf]
233 Gralle, M., and Pääbo, S.: A comprehensive functional analysis of ancestral human signal peptides. Molecular Biology and Evolution 28: 25-28 (2011). [pdf]
234 Albert, F.W., Hodges, E., Jensen, J.D., Besnier, F., Xuan, Z., Rooks, M., Bhattacharjee, A., Brizuela, L., Good, J.M., Green, R.E., Burbano, H., Plyusnina, I.Z., Trut, L., Andersson, L., Schöneberg, T., Carlborg, Ö., Hannon, G.J., and Pääbo, S.: Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection. Heredity, doi:10.1038/hdy.2011.4 (2011). [pdf]
235 Fischer, A., Prüfer, K., Good, J.M., Halbwax, M., Wiebe, V., André, C., Atencia, R., Mugisha, L., Ptak, S.E., and Pääbo, S.: Bonobos fall within the genomic variation of chimpanzees. PLoS ONE 6(6): e21605 (2011). [pdf]
236 Reich, D., Patterson, N., Kircher, M., Delfin, F., Nandineni, M.R., Pugach, I., Ko, A.M., Ko, Y., Jinam, T.A., Phipps, M.E., Saitou, N., Wollstein, A., Kayser, M., Pääbo, S., and Stoneking, M.: Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania. American Journal of Human Genetics 89: 516-528 (2011). [pdf]
237 Brawand, D., Soumillon, M., Necsulea, A., Julien, P., Csárdi, G. Harrigan, P., Weier, M., Liechti, A., Aximu-Petri, A., Kircher, M., Albert, F.W., Zeller, U., Khaitovich, P., Grützner, F., Bergmann, S., Nielsen, R., Pääbo, S., and Kaessmann, H.:The evolution of gene expression levels in mammalian organs. Nature 478: 343-348 (2011). [pdf]
238 Nagaraj, N., Wisniewski, J.R., Geiger, T., Cox, J., Kircher, M., Kelso, J., Pääbo, S., and Mann, M.: Deep proteome and transcriptome mapping of a human cancer cell line. Molecular Systems Biology 7: 548, doi:10.1038/msb.2011.81 (2011). [pdf]
239 Fu, X., Giavalisco, P., Liu, X., Catchpole, G., Fu, N., Ning, Z.B., Guo, S., Yan, Z., Somel, M., Pääbo, S., Zeng, R., Willmitzer, L., and Khaitovich, P.: Rapid metabolic evolution in human prefrontal cortex. Proc. Natl. Acad. Sci. U S A 108:6181-86 (2011). [pdf]
240 Hu, H.Y., Guo, S., Xi, J., Yan, Z., Fu, N., Zhang, X., Menzel, C., Liang, H., Yang, H., Zhao, M., Zeng, R., Chen, W., Pääbo, S., and Khaitovich, P.: MicroRNA expression and regulation in human, chimpanzee, and macaque brains. PLoS Genetics 7(10):e1002327 (2011). [pdf]
241 Ka, S., Albert, F.W., Denbow, D.M., Pääbo, S., Siegel, P.B., Andersson, L., and Hallböök, F.: Differentially expressed genes in hypothalamus in relation to genomic regions under selection in two chicken lines resulting from divergent selection for high or low body weight. Neurogenetics12: 211-21 (2011). [pdf]
242 Somel, M., Liu, X., Tang, L., Yan, Z., Hu, H., Guo, S., Jiang, X., Zhang, X., Xu, G., Xie, G., Li, N., Hu, Y., Chen, W., Pääbo, S., and Khaitovich, P.: MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates. PLoS Biol. 9(12): e1001214 (2011). [pdf]
243 Liu, X., Sohmel, M., Tang, L., Yan, Z., Jiang, X., Guo, S., Yuan, Y., He, L., Oleksiak, A., Zhang, Y., Li, N., Hu, Y., Chen, W., Qiu, Z., Pääbo, S., and P. Khaitovich: Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Research 22: 611-622 (2012). [pdf]
244 Burbano, H.A., Green, R.E., Maricic, T., Lalueza-Fox, C., Rasilla, M. de la, Rosas, A., Kelso, J., Pollard, K.S., Lachmann, M., and Pääbo, S.: Analysis of human accelerated DNA regions using archaic hominin genomes. PLoS ONE 7(3): e32877 (2012). [pdf]
245 Fu, Q., Rudan, P., Pääbo, S., and Krause, J.:Complete mitochondrial genomes reveal Neolithic expansion into Europe. PLoS ONE 7(3): e32473 (2012).[pdf]
246 Prüfer, K., Munch, K., Hellmann, I., Akagi, K., Miller, J.R., Walenz, B., Koren, S., Sutton, G., Kodira, C., Winer, R., Knight, J.R., Mullikin, J.C., Meader, S.J., Ponting, C.P., Lunter, G., Higashino, S., Hobolth, A., Dutheil, J., Karakoҫ, E., Alkan, C., Sajjadian, S., Catacchio, C.R., Ventura, M., Marques-Bonet, T., Eichler, E.E., André, C., Atencia, R., Mugisha, L., Patterson, N., Siebauer, M., Good, J.M., Fischer, A., Ptak, S.E., Lachmann, M., Symer, D.E., Mailund, T., Schierup, M.H., Andrés, A.M., Kelso, J., and Pääbo, S.: The bonobo genome compared with the chimpanzee and human genomes. Nature 486: 527-531 (2012). [pdf]
247 Sawyer, S., Krause, J., Guschanski, K., Savolainen, V., and Pääbo, S.: Temporal patterns of nucleotide misincorporations and DNA fragmentation in ancient DNA. PLoS ONE 7(3): e34131 (2012). [pdf]
248 Fietz, S.A., Lachmann, R., Brandl, H., Kircher, M., Samusik, N., Schröder, R., Lakshmanaperumal, N., Henry, I., Vogt, J., Riehn, A., Distler, W., Nitsch, R., Enard, W., Pääbo, S., and Huttner, W.B.: Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal, PNAS 109: 11836-41 (2012). [pdf]
249 Langergraber, K.E., Prüfer, K., Rowney, C., Boesch, C., Crockford, C., Fawcett, K., Inoue, E., Inoue-Muruyama, M., Mitani, J.C., Muller, M.N., Robbins, M.M., Schubert, G., Stoinski, T., Viola, B., Watts, D., Wittig, R.M., Wrangham, R.W., Zuberbühler, K., Pääbo, S., and Vigilant, L.: Generation times in wild chimpanzees and gorillas suggest earlier divergence times in great ape and human evolution. PNAS 109: 15716-21 (2012). [pdf]
250 Meyer, M., Kircher, M., Gansauge, M.-T., Li, H., Racimo, F., Mallick, S., Schraiber, J.G., Jay, F., Prüfer, K., de Filippo, C., Sudmant, C., Alkan, P.H., Fu, Q., Do, R., Rohland, N., Tandon, A., Siebauer, M., Green, R.E., Bryc, K., Briggs, A.W., Stenzel, U., Dabney, J., Shendure, J., Kitzman, J., Hammer, M.F., Shunkov, M.V., Derevianko, A.P., Patterson, N., Andrés, A.M., Eichler, E.E., Slatkin, M., Reich, D., Kelso, J., and Pääbo, S.: A high coverage genome sequence from an archaic Denisovan individual. Science 338: 222-226, doi: 10.1126/science.1224344 (2012) [Read online]
251 Albert, F.W., Somel, M., Carneiro, M., Aximu-Petri, A., Halbwax, M., Thalmann, O., Blanco-Aguiar, J.A., Plyusnina, I.Z., Trut, L., Villafuerte, R., Ferrand, N., Kaiser, S., Jensen, P., and Pääbo S.: A comparison of brain gene expression levels in domesticated and wild animals. PLoS Genetics 8(9): e1002962 (2012). [pdf]
252 Sankararaman, S., Patterson, N., Li, H., Pääbo, S., and D. Reich: The date of interbreeding between Neandertals and modern humans. PLoS Genetics 8(10): e1002947. doi:10.1371/journal.pgen.1002947 (2012) [pdf]
253 Maricic, T., Günther, V., Georgiev, O., Gehre, S., Ćurlin, M., Schreiweis, C., Naumann, R., Burbano, H.A., Meyer, M., Lalueza-Fox, C., de la Rasilla, M., Rosas, A., Gajović, S., Kelso, J., Enard, W., Schaffner, W., and Pääbo, S.: A recent evolutionary change affects a regulatory element in the human FOXP2 gene. Molecular Biology and Evolution 30(4): 844-852 (2013). [pdf]
254 Good, J.M., Wiebe, V., Albert, F.W., Burbano, H.A., Kircher, M., Green, R.E., Halbwax, M., André, C., Atencia, R., Fischer, A., and Pääbo, S.: Comparative population genomics of the ejaculate in humans and the great apes. Molecular Biology and Evolution 30(4): 964-976 (2013). [pdf]
255 Fu, Q., Meyer, M., Gao, X., Stenzel, U. Burbano, H.A., Kelso, J., and Pääbo, S.: DNA analysis of an early modern human from Tianyuan Cave, China. PNAS 110: 2223-27 (2013). [pdf]
256 Fu, Q., Mittnik, A., Johnson, P.L.F., Bos, K., Lari, M., Bollongino, R., Sun, C., Giemsch, L., Schmitz, R., Burger, J., Ronchitelli, A.M., Martini, F., Cremonesi, R.G., Svoboda, J., Bauer, P., Caramelli, D., Castellano, S., Reich, D., Pääbo, S. and Krause, J.: A revised timescale for human evolution based on ancient mitochondrial genomes. Current Biology 23: 553-559 (2013). [pdf]
257 Ka, S., Markljung, E., Ring, H., Albert, F.W., Harun-Or-Rashid, M., Wahlberg, P., Garcia-Roves, P.M., Zierath, J.R., Denbow, D.M., Pääbo, S., Siegel, P.B., Andersson, L., and Hallbook, F.: The expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight. Physiological Genomics 45: 367-376 (2013). [pdf]
258 Dabney, J., Knapp, M., Glocke, I., Gansauge, M.-T., Weihmann, A., Nickel, B., Valdiosera, C., Garcia, N., Pääbo, S., Arsuaga, J.-L., and Meyer, M.: Complete mitochondrial genome sequence of a Middle Pleistocene cave bear recontructed from ultrashort DNA fragments. PNAS 110: 15758-63 (2013). [pdf]
259 Kuhlwilm, M., Davierwala, A., and Pääbo, S.: Identification of putative target genes of the transcription factor RUNX2. PLOS ONE 8(12): e83218 (2013) [pdf]
260 Thalmann, O., Shapiro, B., Cui, P., Schuenemann, V.J., Sawyer, S.K., Greenfield, D.L., Germonpré, M.B., Sablin, M.V., López-Giráldez, F., Domingo-Roura, X., Napierala, H., Uerpmann, H.-P., Laponte, D.M., Acosta, A.A., Giemsch, L., Schmitz, R.W., Worthington, B., Buikstra, J.E., Druzhkova, A., Graphodatsky, A.S., Ovodov, N.D., Wahlberg, N., Freedman, A.H., Schweizer, R.M., Koepfli, K.-P., Leonard, J.A., Meyer, M., Krause, J., Pääbo, S., Green, R.E., and Wayne, R.K.: Complete mitochondrial genomes of ancient canids suggest a European origin of domestic dogs. Science 342: 871-874 (2013). [pdf]
261 The SIGMA Type 2 Diabetes Consortium: Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature 506: 97-101 (2014). [pdf]
262 Prüfer, K., Racimo, F., Patterson, N., Jay, F., Sankararaman, S., Sawyer, S., Heinze, A., Renaud, G., Sudmant, P.H., de Filippo, C., Li, H., Mallick, S., Dannemann, M., Fu, Q., Kircher, M., Kuhlwilm, M., Lachmann, M., Meyer, M., Ongyerth, M., Siebauer, M., Theunert, C., Tandon, A., Moorjani, P., Pickrell, J., Mullikin, J.C., Vohr, S.H., Green, R.E., Hellmann, I., Johnson, P.L.F., Blanche, H., Cann, H., Kitzman, J.O., Shendure, J., Eichler, E.E., Lein, E.S., Bakken, T.E., Golovanova, L.V., Doronichev, V.B., Shunkov, M.V., Derevianko, A.P., Viola, B., Slatkin, M., Reich, D., Kelso, J., and Pääbo, S.: The complete genome sequence of a Neandertal from the Altai Mountains. Nature 505: 43-49 (2014). [pdf]
263 Meyer, M., Fu, Q., Aximu-Petri, A., Glocke, I., Nickel, B., Arsuaga, J.-L., Martínez, I., Gracia, A., Bermúdez de Castro, J.M., Carbonell, E., and Pääbo, S.: A mitochondrial genome sequence of a hominin from Sima de los Huesos. Nature 505: 403-406 (2014). [pdf]
264 Skoglund, P., Northoff, B.H., Shunkov, M.V. Derevianko, A.P., Pääbo, S., Krause, J., and Jakobsson, M.: Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal. PNAS 111: 2229-34 (2014). [pdf]
265 Sankararaman, S., Mallick, S., Dannemann, M., Prüfer, K., Kelso, J., Pääbo, S., Patterson, N., and Reich, D.: The genomic landscape of Neanderthal ancestry in present-day humans. Nature 507: 354-357 (2014). [pdf]
266 Khrameeva, E., Bozek, K., He, L., Yan, Z., Jiang, X., Wei, Y., Tang, K., Gelfand, M.S. Prüfer, K., Kelso, J., Pääbo, S., Giavalisco, P., Lachmann, M., and Khaitovich, P.: Neanderthal ancestry drives evolution of lipid catabolism in contemporary Europeans. Nature Communications 5:3584, doi:10.1038/ncomms4584 (2014). [pdf]
267 Pääbo, S.: The human condition – a molecular approach. Cell 157: 216-226 (2014) (Review). [pdf]
268 Castellano, S., Parra, G., Sánchez-Quinto, F., Racimo, F., Kuhlwilm, M., Kircher, M., Sawyer, S., Fu, Q., Heinze, A., Nickel, B., Dabney, J., Siebauer, M., White, L., Burbano, H.A., Renaud, G., Stenzel, U., Lalueza-Fox, C., de la Rasilla, M., Rosas, A., Rudan, P., Brajkovic, D., Kucan, Ž., Gušic, I., Shunkov, M.V., Derevianko, A.P., Viola, B., Meyer, M., Kelso, J., Andrés, A.M., and Pääbo, S.: Patterns of coding variation in the complete exomes of three Neandertals. PNAS 111: 6666-71 (2014). [pdf]
269 Gokhman, D., Lavi, E., Prüfer, K., Fraga, M.F., Riancho, J.A., Kelso, J., Pääbo, S., Meshorer, E., and Carmel, L.: Reconstructing the DNA methylation maps of the Neandertal and the Denisovan. Science 344: 523-527 (2014). [pdf]
270 Lindskog, C., Kuhlwilm, M., Davierwala, A., Fu, N., Hegde, G., Uhlén, M., Navani, S., Pääbo, S., and Pontén, F.: Analysis of candidate genes for lineage-specific expression changes in humans and primates. Journal of Proteome Reserarch 13: 3596-3606 (2014). [pdf]
271 Wunderlich, S., Kircher, M., Vieth, B., Haase, A., Merkert, S., Beier, J., Göhring, G., Glage, S., Schambach, A., Curnow, E.C., Pääbo, S., Martin, U., and Enard, W.: Primate iPS cells as tools for evolutionary analyses. Stem cell research 12: 622-629 (2014). [pdf]
272Schreiweis, C., Bornschein, U., Burguière, E., Kerimoglu, C., Schreiter, S., Dannemann, M., Goyal, S., Rea, E., French, C.A., Puliyadi, R., Groszer, M., Fisher, S.E., Mundry, R., Winter, C., Hevers, W., Pääbo, S., Enard, W., and Graybiel, A.M.: Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance. PNAS 111: 14253-58 (2014). [pdf]
273Lazaridis, I., Patterson, N., Mittnik, A., Renaud, G., Mallick, S., Kirsanow, K., Sudmant, P.H., Schraiber, J.G., Castellano, S., Lipson, M., Berger, B., Economou, C., Bollongino, R., Fu, Q., Bos, K., Nordenfelt, S., Li, H., de Filippo, C., Prüfer, K., Sawyer, S., Posth, C., Haak, W., Hallgren, F., Fornander, E., Rohland, N., Delsate, D., Francken, M., Guinet, J.-M., Wahl, J., Ayodo, G., Babiker, H.A., Baillet, G., Balanovska, E., Balanovsky, O., Barrantes, R., Bedoya, G., Ben-Ami, H., Bene, J., Berrada, F., Bravi, C.M., Brisighelli, F., Busby, G.B.J., Cali, F., Churnosov, M., Cole, D.E.C., Corach, D., Damba, L., van Driem, G., Dryomov, S., Dugoujon, J.-M., Fedorova, S.A., Gallego Romero, I., Gubina, M., Hammer, M., Henn, B., Helvig, T., Hodoglugil, U., Jha, A.R., Karachanak-Yankova, S., Khusainova, R., Khusnutdinova, E., Kittles, R., Kivisild, T., Klitz, W., Kučinskas, V., Kushniarevich, A., Laredj, L., Litvinov, S., Loukidis, T., Mahley, R.W., Melegh, B., Metspalu, E., Molina, J., Mountain, J., Näkkäläjärvi, K., Nesheva, D., Nyambo, T., Osipova, L., Parik, J., Platonov, F., Posukh, O.L., Romano, V., Rothhammer, F., Rudan, I., Ruizbakiev, R., Sahakyan, H., Sajantila, A., Salas, A., Starikovskaya, E.B., Tarekegn, A., Toncheva, D., Turdikulova, S., Uktveryte, I., Utevska, O., Vasquez, R., Villena, M., Voevoda, M., Winkler, C., Yepiskoposyan, L., Zalloua, P., Zemunik, T., Cooper, A., Capelli, C., Thomas, M.G., Ruiz-Linares, A., Tishkoff, S.A., Singh, L., Thangaraj, K., Villems, R., Comas, D., Sukernik, R., Metspalu, M., Meyer, M., Eichler, E.E., Burger, J., Slatkin, M., Pääbo, S., Kelso, J., Reich, D., and Krause, J.: Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature 513: 409-413 (2014). [pdf]
274Fu, Q., Li, H., Moorjani, P., Jay, F., Slepchenko, S.M., Bondarev, A.A., Johnson, P.L.F., Aximu-Petri, A., Prüfer, K., Filippo, C. de, Meyer, M., Zwyns, N., Salazar-Garcia, D.C., Kuzmin, Y.V., Keates, S.G., Kosintsev, P.A., Razhev, D.I., Richards, M.P., Peristov, N.V., Lachmann, M., Douka, K., Higham, T.F.G., Slatkin, M., Hublin, J.-J., Reich, D., Kelso, J., Viola, T.B., and Pääbo, S.: Genome sequence of a 45,000-year-old modern human from western Siberia. Nature 514: 445-449 (2014). [pdf]
275Heyne, H., Lautenschläger, S., Nelson, R., Besnier, F., Rotival, M., Cagan, A., Kozhemyakina, R., Plyusnina, I.Z., Trut, L., Carlborg, Ö., Petretto, E., Kruglyak, L., Pääbo, S., Schöneberg, T., and Albert, F.W.: Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics 198: 1277-90 (2014). [pdf]

Book Chapters

1 Hellerström, C., Andersson, A., Björkén, C., Eriksson, U., Groth, C.G., Gunnarsson, R., Hardstedt, C., Lundgren, G., Peterson, B., Pääbo, S., Swenne, I., Agren, A., and Östman, J.: Isolation, culture and trans- plantation of human pancreatic islets. In: Endocrinology (Eds: Cummings, I.A., Funder, J.W., and Mendelsohn, F.A.O.), pp. 368-372 (1980).
2 Kämpe, O., Larhammar, D., Wiman, K., Schenning, L., Claesson, L., Gustafsson, K., Pääbo, S., Hyldig-Nielsen, J.J., Rask, L., and Peterson, P.O.: Molecular analyses of MHC antigens. In: Genetics of the Immune Response (Eds: Möller, E. and Möller, G.), pp. 61-87 (1983).
3 Pääbo, S.: DNA is preserved in ancient Egyptian mummies. In: Science in Egyptology (Ed: David, A.R.), Manchester Univ. Press, pp. 383-388 (1986).
4 Pääbo, S.: Amplifying ancient DNA. In: PCR-Protocols and Applications - A Laboratory Manual (Eds: Innis, M.A., Gelfand, D.H., Sninsky, J.J., and White, T.J.), Academic Pres, San Diego, pp. 159-166 (1990).
5 Simon, C., Pääbo, S., Kocher, T.D., and Wilson, A.C.: Evolution of mitochondrial ribosomal RNA in insects as shown by the polymerase chain reaction. In: Molecular Evolution UCLA Symp. Mol. Cell. Biol., New Series, Vol 122, Alan R. Liss, Inc., pp. 235-244 (1990).
6 Goloubinoff, P., Pääbo, S., and Wilson, A.C.: Molecular characterization of ancient maize: potentials and pitfalls. In: Corn and Culture in the Prehistoric New World (Eds: Johannessen, S., and Hastorf, C.A.), Westview Press, Boulder, CO, pp. 113-125 (1991).
7 Pääbo, S. and Di Rienzo, A.: A molecular approach to the study of Egyptian history. In: Biological Anthropology and the Study of Ancient Egypt (Eds: Davies, V., and Walker, R.), British Museum Press, pp. 86-90 (1993).
8 Höss, M., Handt, O., and Pääbo, S.: Recreating the past by PCR. In: The Polymerase Chain Reaction (Eds: Mullis, K.B., Ferré, F., and Gibbs, R.A.), Birkhauser, Boston, pp. 257-264 (1994).
9 Höss, M. and Pääbo, S.: Ancient DNA. McGraw-Hill Yearbook of Science, pp. 114-116 (1993).
10 Mörl, M., Dörner, M., and Pääbo, S.: Direct purification of tRNAs using oligonucleotides coupled to magnetic beads. In: Advances in Biomagnetic Separation (Eds: Uhlén, M., Hornes, E., and Olsvik, O.), Eaton Publishing, Natick, MA, pp. 107-111 (1994).
11 Pääbo, S.: Gene, Sprache und die Besiedelung des europäischen Nordens-Zum Ursprung von Populationen aus molekulargenetischer Sicht. In: Wie enstehen neue Qualitäten in komplexen Systemen? (Ed: Max-Planck-Gesellschaft), Vandenhoeck & Ruprecht, Göttingen, pp. 49-56 (2000).
12 Poinar, H.N. and Pääbo, S.: DNA. In: Palaeobiology II (Eds: Briggs, D.E.G. and Crowther, P.R.), Blackwell Science, Oxford, pp. 241-245 (2001).
13 Pääbo, S.: Die Wurzeln der Menschheit – die Evolution des humanen Genoms. In: Die Architektur des Lebens – über Gene, Organismen und Personen (Eds: Lessl, M., and Stock, G.), Springer, Berlin, Heidelberg, pp. 39-72 (2002). [pdf]
14 Rabeder, G., Hofreiter, M., Nagel, D., Pääbo, S., and Withalm, G.: Die neue Taxonomy der Höhlenbären. In: Cave bear researches, Abhandlungen zur Karst- und Höhlenkunde, Heft 34 (Eds. Rosendahl, W., Morgan, M., and Correa, M. L. (2002).
15 Pääbo, S.: Ancient DNA. In: DNA - Changing Science and Society. (Ed: Krude, T.), Cambridge University Press, Cambridge, pp. 68-87 (2004).
16 Pääbo, S.: Was ist Forschung? In: Entwurfsatlas Forschungs- und Technologiebau (Eds: Braun, H., and Grömling, D.), Birkhäuser, Basel-Berlin-Boston, pp. 10f (2005). [pdf]
17 Serre, D., Schmitz, R.W., and Pääbo, S.: Genetic analyses of the Neanderthals from the Feldhofer Caves . In: Rheinische Ausgrabungen, Band 58: Neanderthal 1856-2006 (Ed: R.W. Schmitz), Verlag Philipp von Zabern, Mainz am Rhein, pp. 329-333 (2006).
18 Serre, D., Langaney, A., Chech, M., Teschler-Nicola, M., Paunovic, M., Mennecier, P., Hofreiter, M., Possnert, G., and Pääbo, S.: No evidence of Neanderthal mtDNA contribution to early modern humans. In: Early modern humans and the Moravian Gate (Ed: Teschler-Nicola, M.), Springer Verlag, Wien, pp. 491-504 (2006).
19 Serre, D., and Pääbo, S.: The fate of European Neanderthals: results and perspectives from ancient DNA analyses. In: Neanderthals revisited. (Eds.) K. Harvati and T. Harrison, Springer, Dordrecht, The Netherlands, 211-219 (2006).
20 20. Dabney, J., Meyer, M., and Pääbo, S.: Ancient DNA damage. In: DNA repair, mutagenesis, and other responses to DNA damage. (Eds.) E.C. Friedberg et al. Cold Spring Harbor Perspectives in biology http://cshperspectives.cshlp.org/cgi/reprint/cshperspect.a012567v1.pdf?ijkey=zgSzMlNT4ziaM5o&keytype=finite (2013).
21 Viola, B., and Pääbo, S.: What's new in Central Aisa? In: Basic Issues in archaeology, anthropology, and ethnography of Eurasia. Festschrift on the occasion of Anatoly Derevianko's 70th birthday. Institute of Archaeology and Ethnography SB RAS Press, Novosibirsk, pp.555-565 (2013). [pdf]

Books

Pääbo, S.: Neanderthal man: In search of lost genomes. Basic Books, New York (2014).

Book Reviews

1 Pääbo, S.: The mummy of Ramses II reconsidered. Orientalistische Literatur- Zeitung 83(4): 389-394 (1988)
2 Pääbo, S.: Molecular systematics at the crossroads. Trends in Genetics 7: 272 (1991)
3 Pääbo, S.: Molecular Anthropology? Trends in Genetics 9: 255 (1993) [pdf]
4 Pääbo, S.: A revolution in evolution. Nature 386:456 (1997) [pdf]

Patents and Patent Applications

Pääbo, S., and Kilger, C.: Method for the direct, exponential amplification and sequencing of DNA molecules and its application. European patent: EP 1 004 677; US application: 991347, 311723, 33104; Japanese application: 9-351817.
 
Pääbo, S., and Kilger, C.: Method for the uncoupled, direct, exponential amplification and sequencing of DNA molecules with the addition of a second thermostable DNA polymerase and its application. European patent: EP 0 854 196; US applications: 08/991184, 357166, 339103; Japanese application: 9-353367.


Updated 2014-11-07 vm