% pubman genre = article @article{item_1555930, title = {{Intra- and interspecific variation in primate gene expression patterns}}, author = {Enard, Wolfgang and Khaitovich, Philipp and Klose, Joachim and Z{\"o}llner, Sebastian and Hei{\ss}ig, Florian and Giavalisco, P. and Nieselt-Struwe, Kay and Muchmore, E. and Varki, Ajit and Ravid, R. and Doxiadis, G. M. and Bontrop, R. E. and P{\"a}{\"a}bo, Svante}, language = {eng}, issn = {0036-8075}, doi = {10.1126/science.1068996}, year = {2002}, date = {2002-04-12}, abstract = {{Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7{\textpercent} identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects. The underlying genetic basis of many of these differences may be altered gene expression. We have compared the transcriptome in blood leukocytes, liver, and brain of humans, chimpanzees, orangutans, and macaques using microarrays, as well as protein expression patterns of humans and chimpanzees using two-dimensional get electrophoresis. We also studied three mouse species that are approximately as related to each other as are humans, chimpanzees, and orangutans. We identified species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain.}}, journal = {{Science}}, volume = {296}, number = {5566}, pages = {340--343}, }