% pubman genre = article
@article{item_3195514,
title = {{Emergence of human-adapted Salmonella enterica is linked to the Neolithization process}},
author = {Key, Felix Michael and Posth, Cosimo and Esquivel-Gomez, Luis R. and H{\"u}bler, Ron and Spyrou, Maria A. and Neumann, Gunnar and Furtw{\"a}ngler, Anja and Sabin, Susanna and Burri, Marta and Wissgott, Antje and Lankapalli, Aditya Kumar and V{\aa}gene, {\AA}shild J. and Meyer, Matthias and Nagel, Sarah and Tukhbatova, Rezeda I. and Khokhlov, Aleksandr and Chizhevsky, Andrey and Hansen, Svend and Belinsky, Andrey B. and Kalmykov, Alexey and Kantorovich, Anatoly R. and Maslov, Vladimir E. and Stockhammer, Philipp W. and Vai, Stefania and Zavattaro, Monica and Riga, Alessandro and Caramelli, David and Skeates, Robin and Beckett, Jessica and Gradoli, Maria Giuseppina and Steuri, Noah and Hafner, Albert and Ramstein, Marianne and Siebke, Inga and L{\"o}sch, Sandra and Erdal, Yilmaz Selim and Alikhan, Nabil-Fareed and Zhou, Zhemin and Achtman, Mark and Bos, Kirsten I. and Reinhold, Sabine and Haak, Wolfgang and K{\"u}hnert, Denise and Herbig, Alexander and Krause, Johannes},
language = {eng},
issn = {2397-334X},
doi = {10.1038/s41559-020-1106-9},
publisher = {Springer Nature},
address = {London},
year = {2020},
date = {2020-10},
abstract = {{It has been hypothesized that the Neolithic transition towards an agricultural and pastoralist economy facilitated the emergence of human-adapted pathogens. Here, we recovered eight Salmonella enterica subsp. enterica genomes from human skeletons of transitional foragers, pastoralists and agropastoralists in western Eurasia that were up to 6,500 yr old. Despite the high genetic diversity of S. enterica, all ancient bacterial genomes clustered in a single previously uncharacterized branch that contains S. enterica adapted to multiple mammalian species. All ancient bacterial genomes from prehistoric (agro-)pastoralists fall within a part of this branch that also includes the human-specific S. enterica Paratyphi C, illustrating the evolution of a human pathogen over a period of 5,000 yr. Bacterial genomic comparisons suggest that the earlier ancient strains were not host specific, differed in pathogenic potential and experienced convergent pseudogenization that accompanied their downstream host adaptation. These observations support the concept that the emergence of human-adapted S. enterica is linked to human cultural transformations.}},
journal = {{Nature Ecology {\&} Evolution}},
volume = {4},
pages = {324--333},
}