% pubman genre = article
@article{item_3362837,
title = {{Physical activity and fat-free mass during growth and in later life}},
author = {Westerterp, Klaas R and Yamada, Yosuke and Sagayama, Hiroyuki and Ainslie, Philip N and Andersen, Lene F and Anderson, Liam J and Arab, Lenore and Baddou, Issaad and Bedu-Addo, Kweku and Blaak, Ellen E and Blanc, Stephane and Bonomi, Alberto G and Bouten, Carlijn V C and Bovet, Pascal and Buchowski, Maciej S and Butte, Nancy F and Camps, Stefan G J A and Close, Graeme L and Cooper, Jamie A and Das, Sai K and Cooper, Richard and Dugas, Lara R and Ekelund, Ulf and Entringer, Sonja and Forrester, Terrence and Fudge, Barry W and Goris, Annelies H and Gurven, Michael and Hambly, Catherine and El Hamdouchi, Asmaa and Hoos, Marije B and Hu, Sumei and Joonas, Noorjehan and Joosen, Annemiek M and Katzmarzyk, Peter and Kempen, Kitty P and Kimura, Misaka and Kraus, William E and Kushner, Robert F and Lambert, Estelle V and Leonard, William R and Lessan, Nader and Martin, Corby K and Medin, Anine C and Meijer, Erwin P and Morehen, James C and Morton, James P and Neuhouser, Marian L and Nicklas, Theresa A and Ojiambo, Robert M and Pietil{\"a}inen, Kirsi H and Pitsiladis, Yannis P and Plange-Rhule, Jacob and Plasqui, Guy and Prentice, Ross L and Rabinovich, Roberto A and Racette, Susan B and Raichlen, David A and Ravussin, Eric and Reynolds, Rebecca M and Roberts, Susan B and Schuit, Albertine J and Sj{\"o}din, Anders M and Stice, Eric and Urlacher, Samuel S and Valenti, Giulio and Van Etten, Ludo M and Van Mil, Edgar A and Wells, Jonathan C K and Wilson, George and Wood, Brian M. and Yanovski, Jack and Yoshida, Tsukasa and Zhang, Xueying and Murphy-Alford, Alexia J and Loechl, Cornelia U and Luke, Amy H and Pontzer, Herman and Rood, Jennifer and Schoeller, Dale A and Wong, William W and Speakman, John R and group, International Atomic Energy Agency Doubly Labeled Water database},
language = {eng},
issn = {0002-9165},
doi = {10.1093/ajcn/nqab260},
year = {2021},
date = {2021-10},
abstract = {{Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass.A study is presented of the association between FFM and physical activity in relation to age.In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3{\textendash}96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL {\textequals} TEE/REE), and calculation of FFM from isotope dilution.PAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76\{\textpercent} and 85\{\textpercent} of the variation in FFM in females and males {\&}lt; 18 y old, and 32\{\textpercent} and 47\{\textpercent} of the variation in FFM in females and males $\geq$ 18 y old, respectively. In participants {\&}lt; 18 y old, mean FM-adjusted FFM was 1.7 kg (95\{\textpercent} CI: 0.1, 3.2 kg) and 3.4 kg (95\{\textpercent} CI: 1.0, 5.6 kg) higher in a very active participant with PAL {\textequals} 2.0 than in a sedentary participant with PAL {\textequals} 1.5, for females and males, respectively. At age 18 y, height and FM{\textendash}adjusted FFM was 3.6 kg (95\{\textpercent} CI: 2.8, 4.4 kg) and 4.4 kg (95\{\textpercent} CI: 3.2, 5.7 kg) higher, and at age 80 y 0.7 kg (95\{\textpercent} CI: {\textminus}0.2, 1.7 kg) and 1.0 kg (95\{\textpercent} CI: {\textminus}0.1, 2.1 kg) higher, in a participant with PAL {\textequals} 2.0 than in a participant with PAL {\textequals} 1.5, for females and males, respectively.If these associations are causal, they suggest physical activity is a major determinant of body composition as reflected in peak FFM, and that a physically active lifestyle can only partly protect against loss of FFM in aging adults.}},
journal = {{The American Journal of Clinical Nutrition}},
volume = {114},
number = {5},
pages = {1583--1589},
}