% pubman genre = article
@article{item_3516960,
title = {{Major genetic risk factors for Dupuytren{\textquotesingle}s disease are inherited from Neandertals}},
author = {{\AA}gren, Richard and Patil, Snehal and Zhou, Xiang and Sahlholm, Kristoffer and P{\"a}{\"a}bo, Svante and Zeberg, Hugo},
language = {eng},
issn = {1537-1719},
doi = {10.1093/molbev/msad130},
year = {2023},
date = {2023-07},
abstract = {{Dupuytren{\textquotesingle}s disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren{\textquotesingle}s disease, up to $\sim$30\{\textpercent} of men over 60 years suffer from this condition in northern Europe. Here, we meta-analyze 3 biobanks comprising 7,871 cases and 645,880 controls and find 61 genome-wide significant variants associated with Dupuytren{\textquotesingle}s disease. We show that 3 of the 61 loci harbor alleles of Neandertal origin, including the second and third most strongly associated ones (P {\textequals} 6.4 $\times$ 10{\textminus}132 and P {\textequals} 9.2 $\times$ 10{\textminus}69, respectively). For the most strongly associated Neandertal variant, we identify EPDR1 as the causal gene. Dupuytren{\textquotesingle}s disease is an example of how admixture with Neandertals has shaped regional differences in disease prevalence.}},
journal = {{Molecular Biology and Evolution}},
volume = {40},
number = {6},
eid = {msad130},
}