%0 Journal Article
%A Khrameeva, Ekaterina
%A Kurochkin, Ilia
%A Bozek, Katarzyna
%A Giavalisco, Patrick
%A Khaitovich, Philipp
%+ Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Lipidome Evolution in Mammalian Tissues : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0001-F6C1-F
%R 10.1093/molbev/msy097
%7 2018-05-11
%D 2018
%8 01.08.2018
%* Review method: peer-reviewed
%X Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes’ sequence and expression accumulate proportionally to the phylogenetic distances, <2% of the lipidome evolves this way. Yet, lipids constituting this 2% cluster in specific functions shared among all tissues. Among species, human show the largest amount of species-specific lipidome differences. Many of the uniquely human lipidome features localize in the brain cortex and cluster in specific pathways implicated in cognitive disorders.
%K humans, brain, lipidome, molecular evolution, mass spectrometry
%J Molecular Biology and Evolution
%V 35
%N 8
%& 1947
%P 1947 - 1957
%I Oxford University Press
%C Oxford, UK 
%@ 0737-4038