%0 Journal Article
%A Key, Felix Michael
%A Posth, Cosimo
%A Esquivel-Gomez, Luis R.
%A Hübler, Ron
%A Spyrou, Maria A.
%A Neumann, Gunnar
%A Furtwängler, Anja
%A Sabin, Susanna
%A Burri, Marta
%A Wissgott, Antje
%A Lankapalli, Aditya Kumar
%A Vågene, Åshild J.
%A Meyer, Matthias
%A Nagel, Sarah
%A Tukhbatova, Rezeda I.
%A Khokhlov, Aleksandr
%A Chizhevsky, Andrey
%A Hansen, Svend
%A Belinsky, Andrey B.
%A Kalmykov, Alexey
%A Kantorovich, Anatoly R.
%A Maslov, Vladimir E.
%A Stockhammer, Philipp W.
%A Vai, Stefania
%A Zavattaro, Monica
%A Riga, Alessandro
%A Caramelli, David
%A Skeates, Robin
%A Beckett, Jessica
%A Gradoli, Maria Giuseppina
%A Steuri, Noah
%A Hafner, Albert
%A Ramstein, Marianne
%A Siebke, Inga
%A Lösch, Sandra
%A Erdal, Yilmaz Selim
%A Alikhan, Nabil-Fareed
%A Zhou, Zhemin
%A Achtman, Mark
%A Bos, Kirsten I.
%A Reinhold, Sabine
%A Haak, Wolfgang
%A Kühnert , Denise
%A Herbig, Alexander
%A Krause, Johannes
%+ Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society
%T Emergence of human-adapted Salmonella enterica is linked to the Neolithization process : 
%G eng
%U https://hdl.handle.net/21.11116/0000-0005-BA1E-9
%R 10.1038/s41559-020-1106-9
%7 2020-02-24
%D 2020
%* Review method: peer-reviewed
%X It has been hypothesized that the Neolithic transition towards an agricultural and pastoralist economy facilitated the emergence of human-adapted pathogens. Here, we recovered eight Salmonella enterica subsp. enterica genomes from human skeletons of transitional foragers, pastoralists and agropastoralists in western Eurasia that were up to 6,500 yr old. Despite the high genetic diversity of S. enterica, all ancient bacterial genomes clustered in a single previously uncharacterized branch that contains S. enterica adapted to multiple mammalian species. All ancient bacterial genomes from prehistoric (agro-)pastoralists fall within a part of this branch that also includes the human-specific S. enterica Paratyphi C, illustrating the evolution of a human pathogen over a period of 5,000 yr. Bacterial genomic comparisons suggest that the earlier ancient strains were not host specific, differed in pathogenic potential and experienced convergent pseudogenization that accompanied their downstream host adaptation. These observations support the concept that the emergence of human-adapted S. enterica is linked to human cultural transformations.
%J Nature Ecology & Evolution
%V 4
%& 324
%P 324 - 333
%I Springer Nature
%C London
%@ 2397-334X