% pubman genre = article @article{item_1555298, title = {{Initial sequence of the chimpanzee genome and comparison with the human genome}}, author = {The Chimpanzee Sequencing and Analysis Consortium and Mikkelsen, Tarjei S. and Hillier, LaDeana W. and Eichler, Evan E. and Zody, Michael C. and Jaffe, David B. and Yang, Shiaw-Pyng and Enard, Wolfgang and Hellmann, Ines and Lindblad-Toh, Kerstin and Altheide, Tasha K. and Archidiacono, Nicoletta and Bork, Peer and Butler, Jonathan and Chang, Jean L. and Cheng, Ze and Chinwalla, Asif T. and de Jong, Pieter and Delehaunty, Kimberley D. and Fronick, Catrina C. and Fulton, Lucinda L. and Gilad, Yoav and Glusman, Gustavo and Gnerre, Sante and Graves, Tina A. and Hayakawa, Toshiyuki and Hayden, Karen E. and Huang, Xiaoqiu and Ji, Hongkai and Kent, W. James and King, Mary-Claire and Kulbokasl, Edward J. and Lee, Ming K. and Liu, Ge and Lopez-Otin, Carlos and Makova, Kateryna D. and Man, Orna and Mardis, Elaine R. and Mauceli, Evan and Miner, Tracie L. and Nash, William E. and Nelson, Joanne O. and P{\"a}{\"a}bo, Svante and Patterson, Nick J. and Pohl, Craig S. and Pollard, Katherine S. and Pr{\"u}fer, Kay and Puente, Xose S. and Reich, David and Rocchi, Mariano and Rosenbloom, Kate and Ruvolo, Maryellen and Richter, Daniel J. and Schaffner, Stephen F. and Smit, Arian F. A. and Smith, Scott M. and Suyama, Mikita and Taylor, James and Torrents, David and Tuzun, Eray and Varki, Ajit and Velasco, Gloria and Ventura, Mario and Wallis, John W. and Wendl, Michael C. and Wilson, Richard K. and Lander, Eric S. and Waterston, Robert H.}, language = {eng}, doi = {10.1038/nature04072}, year = {2005}, date = {2005-09-01}, abstract = {{Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences that have accumulated since the human and chimpanzee species diverged from our common ancestor, constituting approximately thirty-five million single-nucleotide changes, five million insertion/deletion events, and various chromosomal rearrangements. We use this catalogue to explore the magnitude and regional variation of mutational forces shaping these two genomes, and the strength of positive and negative selection acting on their genes. In particular, we find that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles. We also use the chimpanzee genome as an outgroup to investigate human population genetics and identify signatures of selective sweeps in recent human evolution. (PsycINFO Database Record (c) 2006 APA, all rights reserved) (journal abstract).}}, journal = {{Nature}}, volume = {437}, number = {7055}, pages = {69--87}, }