% pubman genre = article @article{item_2368861, title = {{Increased reproductive success of MHC class II heterozygous males among free-ranging rhesus macaques}}, author = {Sauermann, Ulrike and N{\"u}rnberg, Peter and Bercovitch, Fred and Berard, John and Trefilov, Andrea and Widdig, Anja and Kessler, Matt and Schmidtke, J{\"o}rg and Krawczak, Michael}, language = {eng}, issn = {0340-6717; 1432-1203}, doi = {10.1007/s004390100485}, year = {2001}, date = {2001-03}, abstract = {{. Gene conversion and balancing selection have been invoked to explain the ubiquitous diversity of the antigen-presenting proteins encoded in the vertebrate major histocompatibility complex (MHC). In the present study, direct evidence for over-dominant selection promoting MHC diversity in primates is provided by the observation that, in a large free-ranging population of rhesus macaques, males heterozygous at MHC class II locus Mamu-DQB1 sired significantly more offspring than homozygotes (the male-specific selection coefficient s equals 0.34). This heterozygote advantage appeared to be independent of the actual male Mamu-DQB1 genotype. No similar effect emerged for a captive group of monkeys of similar genetic background but under veterinary care.}}, journal = {{Human Genetics}}, volume = {108}, number = {3}, pages = {249--254}, }