% pubman genre = article @article{item_2442411, title = {{Human organomics: A fresh approach to understanding human development using single-cell transcriptomics}}, author = {Camp, J. Gray and Treutlein, Barbara}, language = {eng}, issn = {0950-1991; 1477-9129}, doi = {10.1242/dev.150458}, year = {2017}, date = {2017}, abstract = {{Skip to Next Section Innovative methods designed to recapitulate human organogenesis from pluripotent stem cells provide a means to explore human developmental biology. New technologies to sequence and analyze single-cell transcriptomes can deconstruct these {\textquoteleft}organoids{\textquoteright} into constituent parts, and reconstruct lineage trajectories during cell differentiation. In this Spotlight article we summarize the different approaches to performing single-cell transcriptomics on organoids, and discuss the opportunities and challenges of applying these techniques to generate organ-level, mechanistic models of human development and disease. Together, these technologies will move past characterization to the prediction of human developmental and disease-related phenomena.}}, journal = {{Development}}, volume = {144}, number = {9}, pages = {1584--1587}, }