% pubman genre = article
@article{item_2616193,
title = {{Current challenges in plant eco-metabolomics}},
author = {Peters, Kristian and Worrich, Anja and Weinhold, Alexander and Alka, Oliver and Balcke, Gerd and Birkemeyer, Claudia and Bruelheide, Helge and Calf, Onno W. and Dietz, Sophie and Duehrkop, Kai and Gaquerel, Emmanuel and Heinig, Uwe and Kuecklich, Marlen and K{\"u}cklich, Marlen and Macel, Mirka and Mueller, Caroline and Poeschl, Yvonne and Pohnert, Georg and Ristok, Christian and Rodriguez, Victor Manuel and Ruttkies, Christoph and Schuman, Meredith and Schweiger, Rabea and Shahaf, Nir and Steinbeck, Christoph and Tortosa, Maria and Treutler, Hendrik and Ueberschaar, Nico and Velasco, Pablo and Weiss, Brigitte M. and Widdig, Anja and Neumann, Steffen and van Dam, Nicole M.},
language = {eng},
issn = {1422-0067},
doi = {10.3390/ijms19051385},
publisher = {MDPI AG},
address = {Basel, Switzerland},
year = {2018},
abstract = {{The relatively new research discipline of Eco-Metabolomics is the application of metabolomics techniques to ecology with the aim to characterise biochemical interactions of organisms across different spatial and temporal scales. Metabolomics is an untargeted biochemical approach to measure many thousands of metabolites in different species, including plants and animals. Changes in metabolite concentrations can provide mechanistic evidence for biochemical processes that are relevant at ecological scales. These include physiological, phenotypic and morphological responses of plants and communities to environmental changes and also interactions with other organisms. Traditionally, research in biochemistry and ecology comes from two different directions and is performed at distinct spatiotemporal scales. Biochemical studies most often focus on intrinsic processes in individuals at physiological and cellular scales. Generally, they take a bottom-up approach scaling up cellular processes from spatiotemporally fine to coarser scales. Ecological studies usually focus on extrinsic processes acting upon organisms at population and community scales and typically study top-down and bottom-up processes in combination. Eco-Metabolomics is a transdisciplinary research discipline that links biochemistry and ecology and connects the distinct spatiotemporal scales. In this review, we focus on approaches to study chemical and biochemical interactions of plants at various ecological levels, mainly plant{\textendash}organismal interactions, and discuss related examples from other domains. We present recent developments and highlight advancements in Eco-Metabolomics over the last decade from various angles. We further address the five key challenges: (1) complex experimental designs and large variation of metabolite profiles; (2) feature extraction; (3) metabolite identification; (4) statistical analyses; and (5) bioinformatics software tools and workflows. The presented solutions to these challenges will advance connecting the distinct spatiotemporal scales and bridging biochemistry and ecology.}},
journal = {{International Journal of Molecular Sciences}},
volume = {19},
number = {5},
eid = {1385},
}