% pubman genre = article
@article{item_2635802,
title = {{Lipidome Evolution in Mammalian Tissues}},
author = {Khrameeva, Ekaterina and Kurochkin, Ilia and Bozek, Katarzyna and Giavalisco, Patrick and Khaitovich, Philipp},
language = {eng},
issn = {0737-4038},
doi = {10.1093/molbev/msy097},
publisher = {Oxford University Press},
address = {Oxford, UK},
year = {2018},
date = {2018-08-01},
abstract = {{Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes{\textquoteright} sequence and expression accumulate proportionally to the phylogenetic distances, {\textless}2{\textpercent} of the lipidome evolves this way. Yet, lipids constituting this 2{\textpercent} cluster in specific functions shared among all tissues. Among species, human show the largest amount of species-specific lipidome differences. Many of the uniquely human lipidome features localize in the brain cortex and cluster in specific pathways implicated in cognitive disorders.}},
journal = {{Molecular Biology and Evolution}},
volume = {35},
number = {8},
pages = {1947--1957},
}