% pubman genre = article @article{item_3024193, title = {{Reduced bonobo MHC class I diversity predicts a reduced viral peptide binding ability compared to chimpanzees}}, author = {Maibach, Vincent and Vigilant, Linda}, language = {eng}, issn = {1471-2148}, doi = {10.1186/s12862-019-1352-0}, publisher = {Springer}, address = {Berlin}, year = {2019}, abstract = {{The highly polymorphic genes of the major histocompatibility complex (MHC) class I are involved in defense against viruses and other intracellular pathogens. Although several studies found reduced MHC class I diversity in bonobos in comparison to the closely related chimpanzee, it is unclear if this lower diversity also influences the functional ability of MHC class I molecules in bonobos. Here, we use a bioinformatic approach to analyze the viral peptide binding ability of all published bonobo MHC class I molecules (n {\textequals}{\th}inspace{\textbraceright}58) in comparison to all published chimpanzee MHC class I molecules (n {\textequals}{\textbraceleft}{\th}inspace161) for the class I loci A, B, C and A-like.}}, journal = {{BMC Evolutionary Biology}}, volume = {19}, eid = {14}, }