% pubman genre = article @article{item_3256944, title = {{Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe}}, author = {Schuenemann, Verena J. and Avanzi, Charlotte and Krause-Kyora, Ben and Seitz, Alexander and Herbig, Alexander and Inskip, Sarah and Bonazzi, Marion and Reiter, Ella and Urban, Christian and Dangvard Pedersen, Dorthe and Taylor, G. Michael and Singh, Pushpendra and Stewart, Graham R. and Velem{\'\i}nsk{\'y}, Petr and Likovsky, Jakub and Marcsik, Ant{\'o}nia and Moln{\'a}r, Erika and P{\'a}lfi, Gy{\"o}rgy and Mariotti, Valentina and Riga, Alessandro and Belcastro, M. Giovanna and Boldsen, Jesper L. and Nebel, Almut and Mays, Simon and Donoghue, Helen D. and Zakrzewski, Sonia and Benjak, Andrej and Nieselt, Kay and Cole, Stewart T. and Krause, Johannes}, language = {eng}, issn = {1553-7366}, doi = {10.1371/journal.ppat.1006997}, publisher = {Public Library of Science}, address = {San Francisco, CA}, year = {2018}, date = {2018}, abstract = {{Author summary Many controversies surround leprosy, which is one of the oldest recorded diseases of humankind. The origin and past spread of its main causative agent, Mycobacterium leprae, remain unknown although many attempts have been made to reconstruct its past from historical and archeological sources. Analysis of ancient M. leprae genomes reconstructed from archaeological remains can contribute greatly to reconstructing the origin and evolution of this pathogen. With a new set of ancient M. leprae genomes from Europe, we traced back a so far unrecognized past diversity, which places Europe as a key region for the early spread and worldwide dissemination of leprosy. Our results hint to the potential dynamic changes in the prevalence of different M. leprae strains in Europe during Antiquity, and highlight the need to study ancient pathogen genomes in order to better understand our past.}}, journal = {{PLoS Pathogens}}, volume = {14}, number = {5}, eid = {e1006997}, }