% pubman genre = article @article{item_3257176, title = {{Genetic diversity of HLA system in three populations from Chihuahua, Mexico: Chihuahua City, Ciudad Ju{\'a}rez and rural Chihuahua}}, author = {Pacheco-Ubaldo, Hanna and Adalid-S{\'a}inz, Carmen and Barquera, Rodrigo and Clayton, S. and Arrieta-Bola{\~n}os, Esteban and Delgado-Aguirre, H{\'e}ctor and Gonz{\'a}lez-Medina, Liliana and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Escare{\~n}o-Montiel, N{\'e}stor and Mor{\'a}n-Mart{\'\i}nez, Javier and Bravo-Acevedo, Alicia and Lona-S{\'a}nchez, Abraham and Gonz{\'a}lez-Mart{\'\i}nez, Marisela del Roc{\'\i}o and Jaramillo-Rodr{\'\i}guez, Yolanda and Salgado-Adame, Antonio and la Cruz, Federico Ju{\'a}rez-de and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.05.014}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 461 Mexicans from the state of Chihuahua living in Chihuahua city (N {\textequals} 119), Ciudad Ju{\'a}rez (N {\textequals} 106) and rural communities (N {\textequals} 236), to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes found in the state of Chihuahua include seven Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in Chihuahua are European (52.12 $\pm$ 0.88 by ML; 41.53 of European haplotypes) and Native American (39.51 $\pm$ 2.17 by ML; 37.45 of Native American haplotypes), while African genetic component was less apparent (8.36 $\pm$ 1.47 by ML; 11.70 of African haplotypes).}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {485--488}, }