% pubman genre = article @article{item_3257177, title = {{Genetic diversity of HLA system in two populations from Nuevo Le{\'o}n, Mexico: Monterrey and rural Nuevo Le{\'o}n}}, author = {Barquera, Rodrigo and Bravo-Acevedo, Alicia and Clayton, Stephen and Mungu{\'\i}a, Tirzo Jes{\'u}s Rodr{\'\i}guez and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Adalid-S{\'a}inz, Carmen and Arrieta-Bola{\~n}os, Esteban and Aquino-Rubio, Guadalupe and Gonz{\'a}lez-Mart{\'\i}nez, Marisela del Roc{\'\i}o and Lona-S{\'a}nchez, Abraham and Mart{\'\i}nez-{\'A}lvarez, Julio C{\'e}sar and Arrazola-Garc{\'\i}a, Mar{\'\i}a Araceli and Delgado-Aguirre, H{\'e}ctor and Gonz{\'a}lez-Medina, Liliana and Pacheco-Ubaldo, Hanna and Ju{\'a}rez-Barreto, Vicencio and Ben{\'\i}tez-Arvizu, Gamaliel and Escare{\~n}o-Montiel, N{\'e}stor and la Cruz, Federico Ju{\'a}rez-de and Jaramillo-Rodr{\'\i}guez, Yolanda and Salgado-Adame, Antonio and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.06.003}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 665 Mexicans from the state of Nuevo Le{\'o}n living in the city of Monterrey (N {\textequals} 226) and rural communities (N {\textequals} 439), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Nuevo Le{\'o}n include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Nuevo Le{\'o}n are Native American (54.53 $\pm$ 0.87 by ML; 48.88 of Native American haplotypes) and European (38.67 $\pm$ 4.06 by ML; 32.59 of European haplotypes), and a less prominent African genetic component (6.80 $\pm$ 4.30 by ML; 8.26 of African haplotypes).}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {516--518}, eid = {2019.06.003}, }