% pubman genre = article @article{item_3257179, title = {{Genetic diversity of HLA system in two populations from Durango, Mexico: Durango city and rural Durango}}, author = {Gonz{\'a}lez-Medina, Liliana and Barquera, Rodrigo and Delgado-Aguirre, H{\'e}ctor and Clayton, Stephen and Adalid-S{\'a}inz, Carmen and Arrieta-Bola{\~n}os, Esteban and Pacheco-Ubaldo, Hanna and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Escare{\~n}o-Montiel, N{\'e}stor and Mor{\'a}n-Mart{\'\i}nez, Javier and Bravo-Acevedo, Alicia and Lona-S{\'a}nchez, Abraham and Gonz{\'a}lez-Mart{\'\i}nez, Marisela del Roc{\'\i}o and Jaramillo-Rodr{\'\i}guez, Yolanda and Salgado-Adame, Antonio and la Cruz, Federico Ju{\'a}rez-de and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.06.005}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 479 Mexicans from the state of Durango living in Durango city (N {\textequals} 153) and rural communities (N {\textequals} 326), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Durango include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Durango are European (54.34 $\pm$ 1.68) and Native American (45.66 $\pm$ 2.24), while African genetic component was virtually absent (0.00 $\pm$ 2.03). However, African haplotypes could be estimated at a proportion of 9.13.}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {489--491}, }