% pubman genre = article @article{item_3257183, title = {{Genetic diversity of HLA system in six populations from Jalisco, Mexico: Guadalajara city, Tlajomulco, Tlaquepaque, Tonal{\'a}, Zapopan and rural Jalisco}}, author = {Bravo-Acevedo, Alicia and Escobedo-Ru{\'\i}z, Araceli and Barquera, Rodrigo and Clayton, Stephen and Garc{\'\i}a-Arias, V{\'\i}ctor Eduardo and Arrieta-Bola{\~n}os, Esteban and Gon{\'e}-V{\'a}zquez, Isis and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Arellano-Prado, Francia Paulina and Rodr{\'\i}guez-L{\'o}pez, Marla Estefan{\'\i}a and de S{\'a}nchez-Fern{\'a}ndez, Mar{\'\i}a Guadalupe Jes{\'u}s and Sandoval-Sandoval, Mario J. and G{\'o}mez-Navarro, Benjam{\'\i}n and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.05.012}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 2046 Mexicans from the state of Jalisco living in the city of Guadalajara (N {\textequals} 1189), Tlajomulco (N {\textequals} 30), Tlaquepaque (N {\textequals} 39), Tonal{\'a} (N {\textequals} 35), Zapopan (N {\textequals} 168) and rural communities (N {\textequals} 585), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Jalisco include nine Native American most probable ancestry and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Jalisco are European (48.45 $\pm$ 1.18 by ML; 41.66 of European haplotypes) and Native American (44.02 $\pm$ 1.24 by ML; 39.86 of Native American haplotypes), while African genetic component is less apparent (7.53 $\pm$ 0.30 by ML; 9.62 of African haplotypes).}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {502--505}, }