% pubman genre = article @article{item_3257229, title = {{Genetic diversity of HLA system in six populations from Mexico City Metropolitan Area, Mexico: Mexico City North, Mexico City South, Mexico City East, Mexico City West, Mexico City Center and rural Mexico City}}, author = {Barquera, Rodrigo and Mart{\'\i}nez-{\'A}lvarez, Julio C{\'e}sar and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Bravo-Acevedo, Alicia and Ju{\'a}rez-Nicol{\'a}s, Francisco and Arriaga-Perea, Agust{\'\i}n Jeric{\'o} and Vega-Mart{\'\i}nez, Mar{\'\i}a del Rosario and Ortega-Y{\'a}{\~n}ez, Andrea and Ben{\'\i}tez-Arvizu, Gamaliel and Arrieta-Bola{\~n}os, Esteban and Clayton, Stephen and Ju{\'a}rez-Cort{\'e}s, Eva Dolores and L{\'o}pez-Gil, Concepci{\'o}n and Garc{\'\i}a-{\'A}lvarez, Raquel and Arrazola-Garc{\'\i}a, Mar{\'\i}a Araceli and Mart{\'\i}nez-Bezies, Virginia and Ju{\'a}rez-Barreto, Vicencio and la Cruz, Flor del Roc{\'\i}o Ramos-de and Mac{\'\i}as-Medrano, Rosa Mar{\'\i}a and M{\'e}ndez-Mani, Patricia and Escutia-Gonz{\'a}lez, Ariadna and Montiel-Hern{\'a}ndez, Gustavo Daniel and Immel, Alexander and de Pav{\'o}n-Vargas, Mar{\'\i}a los {\'A}ngeles and Salgado-Galicia, Norma and Novelo-Garza, B{\'a}rbara and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.07.297}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1217 Mexicans from the Mexico City Metropolitan Area living in the northern (N {\textequals} 751), southern (N {\textequals} 52), eastern (N {\textequals} 79), western (N {\textequals} 33), and central (N {\textequals} 152) Mexico City, and rural communities (N {\textequals} 150), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes include 11 Native American haplotypes. Admixture estimates revealed that the main genetic components are Native American (63.85 $\pm$ 1.55 by ML; 57.19 of Native American haplotypes) and European (28.53 $\pm$ 3.13 by ML; 28.40 of European haplotypes), and a less apparent African genetic component (7.61 $\pm$ 1.96 by ML; 7.17 of African haplotypes).}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {539--543}, }