% pubman genre = article @article{item_3257231, title = {{Genetic diversity of HLA system in three populations from Coahuila, Mexico: Torre{\'o}n, Saltillo and rural Coahuila}}, author = {Adalid-S{\'a}inz, Carmen and Barquera, Rodrigo and Crawford, Michael H. and Lona-S{\'a}nchez, Abraham and Clayton, Stephen and Arrieta-Bola{\~n}os, Esteban and Delgado-Aguirre, H{\'e}ctor and Gonz{\'a}lez-Medina, Liliana and Pacheco-Ubaldo, Hanna and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Bravo-Acevedo, Alicia and Escare{\~n}o-Montiel, N{\'e}stor and Mor{\'a}n-Mart{\'\i}nez, Javier and Gonz{\'a}lez-Mart{\'\i}nez, Marisela del Roc{\'\i}o and Jaramillo-Rodr{\'\i}guez, Yolanda and Salgado-Adame, Antonio and la Cruz, Federico Ju{\'a}rez-de and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.07.284}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 684 Mexicans from the state of Coahuila living in Saltillo (N {\textequals} 72), Torre{\'o}n (N {\textequals} 396) and rural communities (N {\textequals} 216), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Coahuila include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Coahuila are European (49.72 $\pm$ 4.18 by ML; 37.49 of European haplotypes) and Native American (45.01 $\pm$ 2.69 by ML; 42.98 of Native American haplotypes), while African genetic component is less apparent (5.27 $\pm$ 1.88 by ML; 9.92 of African haplotypes).}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {492--495}, }