% pubman genre = article @article{item_3257232, title = {{Genetic diversity of HLA system in two populations from Oaxaca, Mexico: Oaxaca city and rural Oaxaca}}, author = {Hern{\'a}ndez-Hern{\'a}ndez, Ofelia and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Barquera, Rodrigo and Warinner, Christina G. and L{\'o}pez-Gil, Concepci{\'o}n and Arrieta-Bola{\~n}os, Esteban and Clayton, Stephen and Bravo-Acevedo, Alicia and la Cruz, Flor del Roc{\'\i}o Ramos-de and M{\'e}ndez-Mani, Patricia and de Pav{\'o}n-Vargas, Mar{\'\i}a los {\'A}ngeles and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.07.278}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 636 Mexicans from the state of Oaxaca living in the city of Oaxaca (N {\textequals} 151) and rural communities (N {\textequals} 485), to obtain information regarding allelic and haplotypic frequencies. We found that the 13 most frequent haplotypes in Oaxaca are all of putative Native American origin. Admixture estimates revealed that the main genetic components in the state of Oaxaca are Native American (73.12 $\pm$ 2.77 by ML; 61.52 of Native American haplotypes) and European (17.36 $\pm$ 2.07 by ML; 20.69 of European haplotypes), and a relatively high African genetic component (9.52 $\pm$ 0.88 by ML; 8.94 of African haplotypes).}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {553--556}, }