% pubman genre = article @article{item_3257237, title = {{Genetic diversity of HLA system in two populations from Hidalgo, Mexico: Pachuca and rural Hidalgo}}, author = {Barquera, Rodrigo and Mart{\'\i}nez-{\'A}lvarez, Julio C{\'e}sar and Trejo-Ordoz, Alondra Victoria and de Pav{\'o}n-Vargas, Mar{\'\i}a los {\'A}ngeles and Vega-Mart{\'\i}nez, Mar{\'\i}a del Rosario and Arrieta-Bola{\~n}os, Esteban and Clayton, Stephen and Ortega-Y{\'a}{\~n}ez, Andrea and Ju{\'a}rez-Cort{\'e}s, Eva Dolores and Ju{\'a}rez-Nicol{\'a}s, Francisco and L{\'o}pez-Gil, Concepci{\'o}n and Immel, Alexander and Arrazola-Garc{\'\i}a, Mar{\'\i}a Araceli and Ju{\'a}rez-Barreto, Vicencio and Ben{\'\i}tez-Arvizu, Gamaliel and Arriaga-Perea, Agust{\'\i}n Jeric{\'o} and Mart{\'\i}nez-Bezies, Virginia and Mac{\'\i}as-Medrano, Rosa Mar{\'\i}a and la Cruz, Flor del Roc{\'\i}o Ramos-de and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Bravo-Acevedo, Alicia and M{\'e}ndez-Mani, Patricia and Escutia-Gonz{\'a}lez, Ariadna Berenice and Montiel-Hern{\'a}ndez, Gustavo Daniel and Garc{\'\i}a-{\'A}lvarez, Raquel and Salgado-Galicia, Norma and Novelo-Garza, B{\'a}rbara and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.07.293}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 122 Mexicans from the state of Hidalgo living in the city of Pachuca (N {\textequals} 41) and rural communities (N {\textequals} 81), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in Hidalgo include eight Native American and one European haplotypes. Admixture estimates revealed that the main genetic components in Hidalgo are Native American (58.93 $\pm$ 2.16 by ML; 54.51 of Native American haplotypes) and European (32.49 $\pm$ 2.88 by ML; 28.69 of European haplotypes), and a relatively high African genetic component (8.58 $\pm$ 0.93 by ML; 6.97 of African haplotypes).}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {535--538}, }