% pubman genre = article @article{item_3257250, title = {{Genetic diversity of HLA system in two populations from Colima, Mexico: Colima city and rural Colima}}, author = {Barquera Lozano, Rodrigo Jos{\'e} and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Arellano-Prado, Francia Paulina and Gon{\'e}-V{\'a}zquez, Isis and Clayton, Stephen and Arrieta-Bola{\~n}os, Esteban and Escobedo-Ru{\'\i}z, Araceli and Garc{\'\i}a-Arias, V{\'\i}ctor Eduardo and Bravo-Acevedo, Alicia and Rodr{\'\i}guez-L{\'o}pez, Marla Estefan{\'\i}a and S{\'a}nchez-Fern{\'a}ndez, Mar{\'\i}a Guadalupe de Jes{\'u}s and Sandoval-Sandoval, Mario J. and G{\'o}mez-Navarro, Benjam{\'\i}n and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.06.004}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 104 Mexicans from the state of Colima living in the city of Colima (N {\textequals} 61) and rural communities (N {\textequals} 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Colima include eight Native American, two European and one African haplotype. Admixture estimates revealed that the main genetic components in the state are Native American (52.74 $\pm$ 3.88 by ML; 48.10 of Native American haplotypes) and European (37.52 $\pm$ 8.94 by ML; 26.66 of European haplotypes), and a relatively high African genetic component (9.74 $\pm$ 8.40 by ML; 11.91 of African haplotypes). {\copyright} 2019 American Society for Histocompatibility and Immunogenetics}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {513--515}, }