% pubman genre = article @article{item_3257255, title = {{Genetic diversity of HLA system in three populations from Guanajuato, Mexico: Guanajuato City, Le{\'o}n and rural Guanajuato}}, author = {Pantoja-Torres, Jorge Arturo and Barquera, Rodrigo and Ballesteros-Romero, M{\'o}nica and Bravo-Acevedo, Alicia and Arrieta-Bola{\~n}os, Esteban and Montiel-Hern{\'a}ndez, Gustavo Daniel and Clayton, Stephen and Rodr{\'\i}guez-Rodr{\'\i}guez, Lidia Iris and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Gon{\'e}-V{\'a}zquez, Isis and Escobedo-Ru{\'\i}z, Araceli and Garc{\'\i}a-Arias, V{\'\i}ctor Eduardo and Arellano-Prado, Francia Paulina and Rodr{\'\i}guez-L{\'o}pez, Marla Estefan{\'\i}a and de S{\'a}nchez-Fern{\'a}ndez, Mar{\'\i}a Guadalupe Jes{\'u}s and Sandoval-Sandoval, Mario J. and G{\'o}mez-Navarro, Benjam{\'\i}n and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.06.002}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 262 Mexicans from the state of Guanajuato living in the cities of Guanajuato (N {\textequals} 78), Le{\'o}n (N {\textequals} 22) and rural communities (N {\textequals} 162), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes found in the state of Guanajuato include 12 Native American and three European haplotypes. Admixture estimates revealed that the main genetic components in the state of Guanajuato are Native American (50.64 $\pm$ 2.11 by ML, 43.35 of Native American haplotypes) and European (44.14 $\pm$ 1.14 by ML; 39.35 of European haplotypes), while African genetic component is less apparent (5.22 $\pm$ 2.08 by ML; 8.36 of African haplotypes).}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {510--512}, }