% pubman genre = article @article{item_3257256, title = {{Genetic diversity of HLA system in a population sample from Aguascalientes, Mexico}}, author = {Bravo-Acevedo, Alicia and Barquera, Rodrigo and Arrieta-Bola{\~n}os, Esteban and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Clayton, Stephen and Gon{\'e}-V{\'a}zquez, Isis and Escobedo-Ru{\'\i}z, Araceli and Pantoja-Torres, Jorge Arturo and Adalid-S{\'a}inz, Carmen and Pacheco-Ubaldo, Hanna and Mart{\'\i}nez-{\'A}lvarez, Julio C{\'e}sar and Gonz{\'a}lez-Mart{\'\i}nez, Marisela del Roc{\'\i}o and Lona-S{\'a}nchez, Abraham and Gonz{\'a}lez-Medina, Liliana and Escare{\~n}o-Montiel, N{\'e}stor and Arrazola-Garc{\'\i}a, Mar{\'\i}a Araceli and Ju{\'a}rez-Barreto, Vicencio and Ben{\'\i}tez-Arvizu, Gamaliel and Delgado-Aguirre, H{\'e}ctor and de S{\'a}nchez-Fern{\'a}ndez, Mar{\'\i}a Guadalupe Jes{\'u}s and Sandoval-Sandoval, Mario J. and Jaramillo-Rodr{\'\i}guez, Yolanda and G{\'o}mez-Navarro, Benjam{\'\i}n and Salgado-Adame, Antonio and la Cruz, Federico Ju{\'a}rez-de and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio}, language = {eng}, issn = {0198-8859}, doi = {10.1016/j.humimm.2019.05.016}, publisher = {Elsevier}, address = {New York, N.Y.}, year = {2020}, date = {2020-09}, abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 95 Mexicans from the state of Aguascalientes to obtain information regarding allelic and haplotypic frequencies and their linkage disequilibrium. We find that the most frequent haplotypes in the state of Aguascalientes include four Native American, three European and one Asian haplotypes. Admixture estimates revealed that the main genetic components in the state of Aguascalientes are Native American (54.53 $\pm$ 3.22 by ML; 44.21 of Native American haplotypes) and European (44.34 $\pm$ 0.45 by ML; 40.53 of European haplotypes), and a relatively low African genetic component (1.13 $\pm$ 2.33 by ML; 5.26 of African haplotypes).}}, journal = {{Human Immunology}}, volume = {81}, number = {9}, pages = {519--521}, }