% pubman genre = article
@article{item_3257271,
title = {{A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia}},
author = {Adhikari, Kaustubh and Mendoza-Revilla, Javier and Sohail, Anood and Fuentes-Guajardo, Macarena and Lampert, Jodie and Chac{\'o}n-Duque, Juan Camilo and Hurtado, Malena and Villegas, Valeria and Granja, Vanessa and Acu{\~n}a-Alonzo, Victor and Jaramillo, Claudia and Arias, William and Barquera Lozano, Rodrigo Jos{\'e} and Everardo, Paola and G{\'o}mez-Vald{\'e}s, Jorge and Villamil-Ram{\'\i}rez, Hugo and Silva de Cerqueira, Caio Cesar and Hunemeier, T{\'a}bita and Ramallo, Virginia and Schuler-Faccini, Lavinia and Salzano, Francisco M. and Gonzalez-Jos{\'e}, Rolando and Bortolini, Maria-C{\'a}tira and Canizales-Quinteros, Samuel and Gallo, Carla and Poletti, Giovanni and Bedoya, Gabriel and Rothhammer, Francisco and Tobin, Desmond J. and Fumagalli, Matteo and Balding, David and Ruiz-Linares, Andr{\'e}s},
language = {eng},
issn = {2041-1723},
doi = {10.1038/s41467-018-08147-0},
publisher = {Nature Publishing Group},
address = {London},
year = {2019},
abstract = {{We report a genome-wide association scan in {\textgreater}6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation (in 10q26) and three novel loci for eye pigmentation (in 1q32, 20q13 and 22q12). We demonstrate the presence of multiple independent signals of association in the 11q14 and 15q13 regions (comprising the GRM5/TYR and HERC2/OCA2 genes, respectively) and several epistatic interactions among independently associated alleles. Strongest association with skin pigmentation at 19p13 was observed for an Y182H missense variant (common only in East Asians and Native Americans) in MFSD12, a gene recently associated with skin pigmentation in Africans. We show that the frequency of the derived allele at Y182H is significantly correlated with lower solar radiation intensity in East Asia and infer that MFSD12 was under selection in East Asians, probably after their split from Europeans.}},
journal = {{Nature Communications}},
volume = {10},
eid = {358},
}