% pubman genre = article
@article{item_3257330,
title = {{The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure}},
author = {Barquera, Rodrigo and Hern{\'a}ndez-Zaragoza, Diana Ira{\'\i}z and Bravo-Acevedo, Alicia and Arrieta-Bola{\~n}os, Esteban and Clayton, Stephen and Acu{\~n}a-Alonzo, V{\'\i}ctor and Mart{\'\i}nez-{\'A}lvarez, Julio C{\'e}sar and L{\'o}pez-Gil, Concepci{\'o}n and Adalid-S{\'a}inz, Carmen and Vega-Mart{\'\i}nez, Mar{\'\i}a del Rosario and Escobedo-Ru{\'\i}z, Araceli and Ju{\'a}rez-Cort{\'e}s, Eva Dolores and Immel, Alexander and Pacheco-Ubaldo, Hanna and Gonz{\'a}lez-Medina, Liliana and Lona-S{\'a}nchez, Abraham and Lara-Riegos, Julio and S{\'a}nchez-Fern{\'a}ndez, Mar{\'\i}a Guadalupe de Jes{\'u}s and D{\'\i}az-L{\'o}pez, Rosario and Guizar-L{\'o}pez, Gregorio Ulises and Medina-Escobedo, Carolina Elizabeth and Arrazola-Garc{\'\i}a, Mar{\'\i}a Araceli and Montiel-Hern{\'a}ndez, Gustavo Daniel and Hern{\'a}ndez-Hern{\'a}ndez, Ofelia and la Cruz, Ramos-de and Roc{\'\i}o, Flor del and Ju{\'a}rez-Nicol{\'a}s, Francisco and Pantoja-Torres, Jorge Arturo and Rodr{\'\i}guez-Mungu{\'\i}a, Tirzo Jes{\'u}s and Ju{\'a}rez-Barreto, Vicencio and Delgado-Aguirre, H{\'e}ctor and Escutia-Gonz{\'a}lez, Ariadna Berenice and Gon{\'e}-V{\'a}zquez, Isis and Ben{\'\i}tez-Arvizu, Gamaliel and Arellano-Prado, Francia Paulina and Garc{\'\i}a-Arias, V{\'\i}ctor Eduardo and Rodr{\'\i}guez-L{\'o}pez, Marla Estefan{\'\i}a and M{\'e}ndez-Mani, Patricia and Garc{\'\i}a-{\'A}lvarez, Raquel and Gonz{\'a}lez-Mart{\'\i}nez, Marisela del Roc{\'\i}o and Aquino-Rubio, Guadalupe and Escare{\~n}o-Montiel, N{\'e}stor and V{\'a}zquez-Castillo, Tannya Ver{\'o}nica and Uribe-Duarte, Mar{\'\i}a Guadalupe and Ru{\'\i}z-Corral, Mar{\'\i}a de Jes{\'u}s and Ortega-Y{\'a}{\~n}ez, Andrea and Bernal-Felipe, Natalia and G{\'o}mez-Navarro, Benjam{\'\i}n and Arriaga-Perea, Agust{\'\i}n Jeric{\'o} and Mart{\'\i}nez-Bezies, Virginia and Mac{\'\i}as-Medrano, Rosa Mar{\'\i}a and Aguilar-Campos, Jes{\'u}s Abraham and Sol{\'\i}s-Mart{\'\i}nez, Ra{\'u}l and Serrano-Osuna, Ricardo and Sandoval-Sandoval, Mario J. and Jaramillo-Rodr{\'\i}guez, Yolanda and Salgado-Adame, Antonio and Ju{\'a}rez-de la Cruz, Federico and Novelo-Garza, B{\'a}rbara and Pav{\'o}n-Vargas, Mar{\'\i}a de los {\'A}ngeles and Salgado-Galicia, Norma and Bortolini, Maria C{\'a}tira and Gallo, Carla and Bedoya, Gabriel and Rothhammer, Francisco and Gonz{\'a}lez-Jos{\'e}, Rolando and Ruiz-Linares, Andr{\'e}s and Canizales-Quinteros, Samuel and Romero-Hidalgo, Sandra and Krause, Johannes and Z{\'u}{\~n}iga, Joaqu{\'\i}n and Yunis, Edmond J. and Bekker-M{\'e}ndez, Carolina and Granados, Julio},
language = {eng},
issn = {0198-8859},
doi = {10.1016/j.humimm.2020.06.008},
publisher = {Elsevier},
address = {New York, N.Y.},
year = {2020},
date = {2020-09},
abstract = {{We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF {\textgreater} 1{\textpercent}) HLA haplotypes with significant linkage disequilibrium ($\Delta${\textquoteright}$\geq$0.1) in Mexico (accounting for 20{\textpercent} of the haplotypic diversity of the country) are of primarily Native American ancestry (A{\textasteriskcentered}02{\textasciitilde}B{\textasteriskcentered}39{\textasciitilde}DRB1{\textasteriskcentered}04{\textasciitilde}DQB1{\textasteriskcentered}03:02, A{\textasteriskcentered}02{\textasciitilde}B{\textasteriskcentered}35{\textasciitilde}DRB1{\textasteriskcentered}08{\textasciitilde}DQB1{\textasteriskcentered}04, A{\textasteriskcentered}68{\textasciitilde}B{\textasteriskcentered}39{\textasciitilde}DRB1{\textasteriskcentered}04{\textasciitilde}DQB1{\textasteriskcentered}03:02, A{\textasteriskcentered}02{\textasciitilde}B{\textasteriskcentered}35{\textasciitilde}DRB1{\textasteriskcentered}04{\textasciitilde}DQB1{\textasteriskcentered}03:02, A{\textasteriskcentered}24{\textasciitilde}B{\textasteriskcentered}39{\textasciitilde}DRB1{\textasteriskcentered}14{\textasciitilde}DQB1{\textasteriskcentered}03:01, A{\textasteriskcentered}24{\textasciitilde}B{\textasteriskcentered}35{\textasciitilde}DRB1{\textasteriskcentered}04{\textasciitilde}DQB1{\textasteriskcentered}03:02, A{\textasteriskcentered}24{\textasciitilde}B{\textasteriskcentered}39{\textasciitilde}DRB1{\textasteriskcentered}04{\textasciitilde}DQB1{\textasteriskcentered}03:02, A{\textasteriskcentered}02{\textasciitilde}B{\textasteriskcentered}40:02{\textasciitilde}DRB1{\textasteriskcentered}04{\textasciitilde}DQB1{\textasteriskcentered}03:02, A{\textasteriskcentered}68{\textasciitilde}B{\textasteriskcentered}35{\textasciitilde}DRB1{\textasteriskcentered}04{\textasciitilde}DQB1{\textasteriskcentered}03:02, A{\textasteriskcentered}02{\textasciitilde}B{\textasteriskcentered}15:01{\textasciitilde}DRB1{\textasteriskcentered}04{\textasciitilde}DQB1{\textasteriskcentered}03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8{\textpercent} in the northern part of the country to 81.5{\textpercent} in the southeastern region) and European (ranging from 11.5{\textpercent} in the southeast to 62.6{\textpercent} in northern Mexico). African admixture ranged from 0.0 to 12.7{\textpercent} not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources.}},
contents = {1 Introduction 2 Subjects, materials and methods 2.1 Subjects 2.2 HLA typing 2.3 Statistical analysis 2.3.1 HLA allelic and haplotypic diversity 2.3.2 Admixture proportions calculations 2.3.3 Genetic diversity and genetic substructure assessment 3 Results 3.1 HLA allele groups 3.2 Haplotypic diversity 3.3 Admixture estimates 3.4 Genetic diversity and genetic substructure assessment 4 Discussion 4.1 Admixture estimates in Mexican populations and immunogenetic diversity 4.2 The Native American immunogenetic component in Mexican populations 4.3 Implications of the study of alleles and haplotypes of the HLA system in Mexican populations and final considerations 5 Conclusion},
journal = {{Human Immunology}},
volume = {81},
number = {9},
pages = {461--474},
eid = {2020.06.008},
}