@article{item_3270829,
title = {{Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity}},
author = {Le Duc, Diana and Lin, Chen-Ching and Popkova, Yulia and Yang, Zuqin and Akhil, Velluva and \c{C}akir, M. Volkan and Grunewald, Sonja and Simon, Jan-Christoph and Dietz, Andreas and Dannenberger, Dirk and Garten, Antje and Lemke, Johannes R. and Schiller, J\"urgen and Bl\"uher, Matthias and Nankam, Nono and Arielle, Pamela and Rolle-Kampczyk, Ulrike and von Bergen, Martin and Kelso, Janet and Sch\"oneberg, Torsten},
language = {eng},
issn = {1476-5497},
doi = {10.1038/s41366-020-00716-y},
publisher = {Nature},
year = {2020},
date = {2020},
abstract = {{Elucidation of lipid metabolism and accumulation mechanisms is of paramount importance to understanding obesity and unveiling therapeutic targets. In vitro cell models have been extensively used for these purposes, yet, they do not entirely reflect the in vivo setup. Conventional lipomas, characterized by the presence of mature adipocytes and increased adipogenesis, could overcome the drawbacks of cell cultures. Also, they have the unique advantage of easily accessible matched controls in the form of subcutaneous adipose tissue (SAT) from the same individual. We aimed to determine whether lipomas are a good model to understand lipid accumulation.}},
journal = {{International Journal of Obesity}},
}