% pubman genre = article @article{item_3348715, title = {{Shifts in gut and vaginal microbiomes are associated with cancer recurrence time in women with ovarian cancer}}, author = {Jacobson, David and Moore, Kathleen and Gunderson, Camille and Rowland, Michelle and Austin, Rita and Honap, Tanvi Prasad and Xu, Jiawu and Warinner, Christina and Sankaranarayanan, Krithivasan and Jr, Lewis and M., Cecil}, language = {eng}, issn = {2167-8359}, doi = {10.7717/peerj.11574}, publisher = {PeerJ}, year = {2021}, abstract = {{Many studies investigating the human microbiome-cancer interface have focused on the gut microbiome and gastrointestinal cancers. Outside of human papillomavirus driving cervical cancer, little is known about the relationship between the vaginal microbiome and other gynecological cancers, such as ovarian cancer. In this retrospective study, we investigated the relationship between ovarian cancer, platinum-free interval (PFI) length, and vaginal and gut microbiomes. We observed that Lactobacillus-dominated vaginal communities were less common in women with ovarian cancer, as compared to existing datasets of similarly aged women without cancer. Primary platinum-resistance (PPR) disease is strongly associated with survivability under one year, and we found over one-third of patients with PPR (PFI {\textless} 6 months, n {\textequals} 17) to have a vaginal microbiome dominated by Escherichia ({\textgreater}20{\textpercent} relative abundance), while only one platinum super-sensitive (PFI {\textgreater} 24 months, n {\textequals} 23) patient had an Escherichia-dominated microbiome. Additionally, L. iners was associated with little, or no, gross residual disease, while other Lactobacillus species were dominant in women with {\textgreater}1 cm gross residual disease. In the gut microbiome, we found patients with PPR disease to have lower phylogenetic diversity than platinum-sensitive patients. The trends we observe in women with ovarian cancer and PPR disease, such as the absence of Lactobacillus and presence of Escherichia in the vaginal microbiome as well as low gut microbiome phylogenetic diversity have all been linked to other diseases and/or pro-inflammatory states, including bacterial vaginosis and autoimmune disorders. Future prospective studies are necessary to explore the translational potential and underlying mechanisms driving these associations.}}, journal = {{PeerJ : Life {\&} Environment}}, eid = {11574}, }