% pubman genre = article
@article{item_3359947,
title = {{Mapping the human genetic architecture of COVID-19}},
author = {COVID-19 Host Genetics initiative and including authors and Zeberg, Hugo and Niemi, Mari E. K. and Karjalainen, Juha and Liao, Rachel G. and Neale, Benjamin M. and Daly, Mark and Ganna, Andrea and Pathak, Gita A. and Andrews, Shea J. and Kanai, Masahiro and Veerapen, Kumar and Fernandez-Cadenas, Israel and Schulte, Eva C. and Striano, Pasquale and Marttila, Minttu and Minica, Camelia and Marouli, Eirini and Karim, Mohd Anisul and Wendt, Frank R. and Savage, Jeanne and Sloofman, Laura and Butler-Laporte, Guillaume and Kim, Han-Na and Kanoni, Stavroula and Okada, Yukinori and Byun, Jinyoung and Han, Younghun and Uddin, Mohammed Jashim and Smith, George Davey and Willer, Cristen J. and Buxbaum, Joseph D. and Mehtonen, Juha and Finucane, Hilary and Cordioli, Mattia and Martin, Alicia R. and Zhou, Wei and Pasaniuc, Bogdan and Julienne, Hanna and Aschard, Hugues and Shi, Huwenbo and Yengo, Loic and Polimanti, Renato and Ghoussaini, Maya and Schwartzentruber, Jeremy and Dunham, Ian and Chwialkowska, Karolina and Francescatto, Margherita and Trankiem, Amy and Balaconis, Mary K. and Davis, Lea and Lee, Sulggi and Priest, James and Renieri, Alessandra and Sankaran, Vijay G. and van Heel, David and Deelen, Patrick and Richards, J. Brent and Nakanishi, Tomoko and Biesecker, Les and Kerchberger, V. Eric and Baillie, J. Kenneth and Mari, Francesca and Bernasconi, Anna and Baillie, Stefano Ceri and Canakoglu, Arif and Wolford, Brooke and Faucon, Annika and Dutta, Atanu Kumar and Schurmann, Claudia and Harry, Emi and Birney, Ewan and Nguyen, Huy and Nasir, Jamal and Kaunisto, Mari and Solomonson, Matthew and Dueker, Nicole and Vadgama, Nirmal and Limou, Sophie and Rahmouni, Souad and Mbarek, Hamdi and Darwish, Dima and Uddin, Md Mesbah and Albertos, Raquel and P{\'e}rez-Tur, Jordi and Li, Ruolin and Folkersen, Lasse and Moltke, Ida and Koelling, Nils and Teumer, Alexander and Kousathanas, Athanasios and Utrilla, Alicia and Verdugo, Ricardo A. and Z{\'a}rate, Ruth and Medina-G{\'o}mez, Carolina and G{\'o}mez-Cabrero, David and Carnero-Montoro, Elena and Cadilla, Carmen L. and Moreno-Estrada, Andr{\'e}s and Garmendia, Adriana and Moya, Leire and Sedaghati-Khayat, Bahar and Boua, Palwend{\'e} Romuald and Fav{\'e}, Marie-Julie and Francioli, Laurent and Lema{\c{c}}on, Audrey and Migeotte, Isabelle and Patel, Sanjay and Varnai, Reka and Szentpeteri, Jozsef L. and Sipeky, Csilla and Colombo, Francesca and von Hohenstaufen, Kathrin and Lio, Pietro and Vallerga, Costanza and Wang, Qingbo and Tanigawa, Yosuke and Im, Hogune and Han, Chulho and Song, Han and Lim, Jiwoo and Lee, Younhe and Kim, Sugyeong and Im, Sangyoon and Atanasovska, Biljana and Ahmad, Hajar Fauzan and Boer, Cindy and Jansen, Philip and Franke, Lude and Kaja, El{\.Z}bieta and Pasko, Dorota and Kennis-Szilagyi, Ingrid and Kornilov, Sergey A. and Prijatelj, Vid and Proki{\'c}, Ivana and Sivanadhan, Ilangkumaran and Perumal, Sarala and Esmaeeli, Sahar and Pearson, Nathaniel M. and Auton, Adam and Shelton, Janie F. and Shastri, Anjali J. and Filshtein-Sonmez, Teresa and Coker, Daniella and Symons, Antony and Esparza-Gordillo, Jorge and Aslibekyan, Stella and O{\textquoteright}Connell, Jared and Ye, Chelsea and Weldon, Catherine H. and Perera, Minoli and O{\textquoteright}Leary, Kevin and Tuck, Matthew and O{\textquoteright}Brien, Travis and Meltzer, David and O{\textquoteright}Donnell, Peter and Nutescu, Edith and Yang, Guang and Alarcon, Cristina and Herrmann, Stefanie and Mazurek, Sophia and Banagan, Jeff and Hamidi, Zacharia and Barbour, April and Raffat, Noora and Moreno, Diana and Friedman, Paula and Ferwerda, Bart and van de Beek, Diederik and Brouwer, Matthijs C. and Vlaar, Alexander P. J. and Wiersinga, W. Joost and Posthuma, Danielle and Tissink, Elleke and Zwinderman, Koos H. A. and Uffelmann, Emil and van Agtmael, Michiel and Algera, Anne Geke and van Baarle, Frank and Bax, Diane and Beudel, Martijn and Jan Bogaard, Harm and Bomers, Marije and Bonta, Peter I. and Bos, Lieuwe and Botta, Michela and de Brabander, Justin and de Bree, Godelieve and de Bruin, Sanne and Bugiani, Marianna and Bulle, Esther and Chouchane, Osoul and Cloherty, Alex and Dongelmans, Dave and Elbers, Paul and Fleuren, Lucas and Geerlings, Suzanne and Geerts, Bart and Geijtenbeek, Theo and Girbes, Armand and Goorhuis, Bram and Grobusch, Martin P. and Hafkamp, Florianne and Hagens, Laura and Hamann, Jorg and Harris, Vanessa and Hemke, Robert and Hermans, Sabine M. and Heunks, Leo and Hollmann, Markus and Horn, Janneke and Hovius, Joppe W. and de Jong, D. Menno and Koning, Rutger and van Mourik, Niels and Nellen, Jeannine and Nossent, Esther J. and Paulus, Frederique and Peters, Edgar and van der Poll, Tom and Preckel, Bennedikt and Prins, Jan M. and Raasveld, Jorinde and Reijnders, Tom and Schinkel, Michiel and Schultz, Marcus J. and Schuurman, Alex and Sigaloff, Kim and Smit, Marry and Stijnis, Cornelis S. and Stilma, Willemke and Teunissen, Charlotte and Thoral, Patrick and Tsonas, Anissa and van der Valk, Marc and Veelo, Denise and de Vries, Heder and van Vugt, Mich{\`e}le and Wouters, Dorien and Minnaar, Ren{\'e} P. and Kromhout, Adrie and van Uffelen, J. Kees W. and Wolterman, Ruud A. and Roberts, Genevieve and Park, Danny and Ball, Catherine A. and Coignet, Marie and McCurdy, Shannon and Knight, Spencer and Partha, Raghavendran and Rhead, Brooke},
language = {eng},
isbn = {1476-4687},
doi = {10.1038/s41586-021-03767-x},
year = {2021},
date = {2021},
abstract = {{The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3{\textendash}7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.}},
journal = {{Nature}},
volume = {600},
number = {7889},
pages = {472--477},
}