% pubman genre = article @article{item_3369208, title = {{The major genetic risk factor for severe COVID-19 is associated with protection against HIV}}, author = {Zeberg, Hugo}, language = {eng}, issn = {0027-8424}, doi = {10.1073/pnas.2116435119}, publisher = {National Academy of Sciences}, address = {Washington, D.C.}, year = {2022}, abstract = {{There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative, Nature 600, 472{\textendash}477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. P{\"a}{\"a}bo, Nature 587, 610{\textendash}612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an $\sim$27{\textpercent} lower risk of HIV infection.}}, journal = {{Proceedings of the National Academy of Sciences of the United States of America}}, volume = {119}, number = {9}, eid = {e2116435119}, }