% pubman genre = article
@article{item_3377093,
title = {{Constrained human genes under scrutiny}},
author = {Yengo, Loic and Colleran, Heidi},
language = {eng},
issn = {0028-0836; 1476-4687},
doi = {10.1038/d41586-022-00693-4},
year = {2022},
date = {2022-03-31},
abstract = {{Some genes are constrained, which means that damaging variants of them are removed from the population by natural selection. On page 858, Gardner et al.1 investigated the processes underlying this evolutionary process in humans. They report that having a high overall amount of damaging genetic variation in constrained genes is associated with childlessness in men. The association is linked to only 1{\textpercent} of the chance of childlessness between individuals, but to larger effects over many generations in a population. The findings are consistent with the hypothesis that having a greater burden of damaging genetic variation might affect a man{\textquoteright}s ability to find a mating partner.}},
journal = {{Nature}},
volume = {603},
pages = {799--801},
}