% pubman genre = article
@article{item_3377093,
title = {{Constrained human genes under scrutiny}},
author = {Yengo, Loic and Colleran, Heidi},
language = {eng},
issn = {0028-0836; 1476-4687},
doi = {10.1038/d41586-022-00693-4},
year = {2022},
date = {2022-03-31},
abstract = {{Some genes are constrained, which{\textless}br{\textgreater}means that damaging variants of them{\textless}br{\textgreater}are removed from the population by{\textless}br{\textgreater}natural selection.{\textless}br{\textgreater}On page 858, Gardner et al.1 investigated{\textless}br{\textgreater}the processes underlying this{\textless}br{\textgreater}evolutionary process in humans.{\textless}br{\textgreater}They report that having a high{\textless}br{\textgreater}overall amount of damaging genetic{\textless}br{\textgreater}variation in constrained genes is{\textless}br{\textgreater}associated with childlessness in men.{\textless}br{\textgreater}The association is linked to only 1{\textpercent} of{\textless}br{\textgreater}the chance of childlessness between{\textless}br{\textgreater}individuals, but to larger effects over{\textless}br{\textgreater}many generations in a population.{\textless}br{\textgreater}The findings are consistent with the{\textless}br{\textgreater}hypothesis that having a greater burden{\textless}br{\textgreater}of damaging genetic variation might{\textless}br{\textgreater}affect a man{\textquoteright}s ability to find a mating{\textless}br{\textgreater}partner.}},
journal = {{Nature}},
volume = {603},
pages = {799--801},
}