% pubman genre = article
@article{item_3380171,
title = {{Disentangling signatures of selection before and after European colonization in Latin Americans}},
author = {Mendoza-Revilla, Javier and Chac{\'o}n-Duque, J. Camilo and Fuentes-Guajardo, Macarena and Ormond, Louise and Wang, Ke and Hurtado, Malena and Villegas, Valeria and Granja, Vanessa and Acu{\~n}a-Alonzo, Victor and Jaramillo, Claudia and Arias, William and Barquera, Rodrigo and G{\'o}mez-Vald{\'e}s, Jorge and Villamil-Ram{\'\i}rez, Hugo and Silva de Cerqueira, Caio C. and Badillo Rivera, Keyla M. and Nieves-Col{\'o}n, Maria A. and Gignoux, Christopher R. and Wojcik, Genevieve L. and Moreno-Estrada, Andr{\'e}s and H{\"u}nemeier, T{\'a}bita and Ramallo, Virginia and Schuler-Faccini, Lavinia and Gonzalez-Jos{\'e}, Rolando and Bortolini, Maria-C{\'a}tira and Canizales-Quinteros, Samuel and Gallo, Carla and Poletti, Giovanni and Bedoya, Gabriel and Rothhammer, Francisco and Balding, David and Fumagalli, Matteo and Adhikari, Kaustubh and Ruiz-Linares, Andr{\'e}s and Hellenthal, Garrett},
language = {eng},
isbn = {1537-1719},
doi = {10.1093/molbev/msac076},
year = {2022},
abstract = {{Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insights, the extent to which this process contributed to adaptation remains underexplored. Here, we introduce a novel statistical model, specific to admixed populations, that identifies loci under selection while determining whether the selection likely occurred post-admixture or prior to admixture in one of the ancestral source populations. Through extensive simulations, we show that this method is able to detect selection, even in recently formed admixed populations, and to accurately differentiate between selection occurring in the ancestral or admixed population. We apply this method to genome-wide SNP data of $\sim$4,000 individuals in five admixed Latin American cohorts from Brazil, Chile, Colombia, Mexico, and Peru. Our approach replicates previous reports of selection in the human leukocyte antigen region that are consistent with selection post-admixture. We also report novel signals of selection in genomic regions spanning 47 genes, reinforcing many of these signals with an alternative, commonly used local-ancestry-inference approach. These signals include several genes involved in immunity, which may reflect responses to endemic pathogens of the Americas and to the challenge of infectious disease brought by European contact. In addition, some of the strongest signals inferred to be under selection in the Native American ancestral groups of modern Latin Americans overlap with genes implicated in energy metabolism phenotypes, plausibly reflecting adaptations to novel dietary sources available in the Americas.}},
journal = {{Molecular Biology and Evolution}},
volume = {39},
number = {4},
eid = {msac076},
}