% pubman genre = article @article{item_3388522, title = {{The source of the Black Death in fourteenth-century central Eurasia}}, author = {Spyrou, Maria A. and Musralina, Lyazzat and Gnecchi Ruscone, Guido Alberto and Kocher, Arthur and Borbone, Pier-Giorgio and Khartanovich, Valeri I. and Buzhilova, Alexandra and Djansugurova, Leyla and Bos, Kirsten I. and K{\"u}hnert, Denise and Haak, Wolfgang and Slavin, Philip and Krause, Johannes}, language = {eng}, issn = {0028-0836}, doi = {10.1038/s41586-022-04800-3}, publisher = {Nature Publishing Group}, address = {London}, year = {2022}, date = {2022-06-23}, abstract = {{The origin of the medieval Black Death pandemic (ad 1346{\textendash}1353) has been a topic of continuous investigation because of the pandemic{\textquoteright}s extensive demographic impact and long-lasting consequences1,2. Until now, the most debated archaeological evidence potentially associated with the pandemic{\textquoteright}s initiation derives from cemeteries located near Lake Issyk-Kul of modern-day Kyrgyzstan1,3,4,5,6,7,8,9. These sites are thought to have housed victims of a fourteenth-century epidemic as tombstone inscriptions directly dated to 1338{\textendash}1339 state {\textquoteleft}pestilence{\textquoteright} as the cause of death for the buried individuals9. Here we report ancient DNA data from seven individuals exhumed from two of these cemeteries, Kara-Djigach and Burana. Our synthesis of archaeological, historical and ancient genomic data shows a clear involvement of the plague bacterium Yersinia pestis in this epidemic event. Two reconstructed ancient Y. pestis genomes represent a single strain and are identified as the most recent common ancestor of a major diversification commonly associated with the pandemic{\textquoteright}s emergence, here dated to the first half of the fourteenth century. Comparisons with present-day diversity from Y. pestis reservoirs in the extended Tian Shan region support a local emergence of the recovered ancient strain. Through multiple lines of evidence, our data support an early fourteenth-century source of the second plague pandemic in central Eurasia}}, journal = {{Nature}}, volume = {606}, pages = {718--724}, }