% pubman genre = article @article{item_3389702, title = {{Population genetics and signatures of selection in early Neolithic European farmers}}, author = {Childebayeva, Ainash and Rohrlach, Adam Ben and Barquera Lozano, Rodrigo Jos{\'e} and Rivollat, M and Aron, F and Szolek, A and Kohlbacher, O and Nicklisch, N and Alt, KW and Gronenborn, D and Meller, H and Friederich, S and Pr{\"u}fer, Kay and Deguilloux, M-F and Krause, Johannes and Haak, Wolfgang}, language = {eng}, issn = {0737-4038}, doi = {10.1093/molbev/msac108}, publisher = {Oxford University Press}, address = {Oxford}, year = {2022}, date = {2022-06}, abstract = {{Human expansion in the course of the Neolithic transition in western Eurasia has been one of the major topics in ancient DNA (aDNA) research in the last ten years. Multiple studies have shown that the spread of agriculture and animal husbandry from the Near East across Europe was accompanied by large-scale human expansions. Moreover, changes in subsistence and migration associated with the Neolithic transition have been hypothesized to involve genetic adaptation. Here we present high quality genome-wide data from the Linear Pottery Culture (LBK) site Derenburg Meerenstieg II (DER) (N{\textequals}32 individuals) in Central Germany. Population genetic analyses show that the DER individuals carried predominantly Anatolian Neolithic-like ancestry and a very limited degree of local hunter-gatherer admixture, similar to other early European farmers. Increasing the LBK cohort size to $\sim$100 individuals allowed us to perform various frequency- and haplotype-based analyses to investigate signatures of selection associated with changes following the adoption of the Neolithic lifestyle. In addition, we developed a new method called AIMLESS (Admixture-informed Maximum-likelihood Estimation for Selection Scans) that allowed us test for selection signatures in an admixture-aware fashion. Focusing on the intersection of results from these selection scans, we identified various loci associated with immune function (JAK1, HLA-DQB1) and metabolism (LMF1, LEPR, SORBS1), as well as skin color (SLC24A5, CD82) and folate synthesis (MTHFR, NBPF3). Our findings shed light on the evolutionary pressures, such as infectious disease and changing diet, that were faced by the early farmers of Western Eurasia.}}, journal = {{Molecular Biology and Evolution}}, volume = {39}, number = {6}, eid = {msac108}, }