% pubman genre = article
@article{item_3390952,
title = {{Differential Leukocyte Expression of IFITM1 and IFITM3 in Patients with Severe Pandemic Influenza A(H1N1) and COVID-19}},
author = {Regino-Zamarripa, Nora E. and Ram{\'\i}rez-Mart{\'\i}nez, Gustavo and Jim{\'e}nez-{\'A}lvarez, Luis Armando and Cruz-Lagunas, Alfredo and G{\'o}mez-Garc{\'\i}a, Itzel Alejandra and Ignacio-Cort{\'e}s, Sergio and M{\'a}rquez-Garc{\'\i}a, Jos{\'e} Eduardo and Pacheco-Hern{\'a}ndez, Lynette Miroslava and Ram{\'\i}rez-Noyola, Jazm{\'\i}n Ariadna and Barquera, Rodrigo and Mendoza-Milla, Criselda and Luna-Rivero, Cesar and Dom{\'\i}nguez-Cherit, Jos{\'e} Guillermo and Ram{\'\i}rez-Rangel, Remedios and Rodr{\'\i}guez-Reyna, Tatiana Sof{\'\i}a and Hern{\'a}ndez-C{\'a}rdenas, Carmen M. and Chore{\~n}o-Parra, Jos{\'e} Alberto and Le{\'o}n-{\'A}vila, Gloria and Z{\'u}{\~n}iga, Joaqu{\'\i}n},
language = {eng},
issn = {1079-9907; 1557-7465},
doi = {10.1089/jir.2022.0036},
publisher = {Mary Ann Liebert, Inc., publishers},
year = {2022},
date = {2022-06-14},
abstract = {{Interferon-induced transmembrane (IFITM) proteins mediate protection against enveloped viruses by blocking membrane fusion at endosomes. IFITM1 and IFITM3 are crucial for protection against influenza, and various single nucleotide polymorphisms altering their function have been linked to disease susceptibility. However, bulk IFITM1 and IFITM3 mRNA expression dynamics and their correlation with clinical outcomes have not been extensively addressed in patients with respiratory infections. In this study, we evaluated the expression of IFITM1 and IFITM3 in peripheral leukocytes from healthy controls and individuals with severe pandemic influenza A(H1N1) or coronavirus disease 2019 (COVID-19). Comparisons between participants grouped according to their clinical characteristics, underlying disease, and outcomes showed that the downregulation of IFITM1 was a distinctive characteristic of severe pandemic influenza A(H1N1) that correlated with outcomes, including mortality. Conversely, increased IFITM3 expression was a common feature of severe pandemic influenza A(H1N1) and COVID-19. Using a high-dose murine model of infection, we confirmed not only the downregulation of IFITM1 but also of IFITM3 in the lungs of mice with severe influenza, as opposed to humans. Analyses in the comparative cohort also indicate the possible participation of IFITM3 in COVID-19. Our results add to the evidence supporting a protective function of IFITM proteins against viral respiratory infections in humans.}},
journal = {{Journal of Interferon {\&} Cytokine Research}},
volume = {42},
number = {8},
pages = {430--443},
}