% pubman genre = article
@article{item_3451101,
title = {{Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes}},
author = {Dannemann, Michael and Milaneschi, Yuri and Yermakovich, Danat and Stiglbauer, Victoria and Kariis, Hanna Maria and Krebs, Kristi and Friese, Manuel A. and Otte, Christian and Esko, T{\~o}nu and Metspalu, Andres and Milani, Lili and M{\"a}gi, Reedik and Nelis, Mari and Lehto, Kelli and Penninx, Brenda W. J. H. and Kelso, Janet and Gold, Stefan M. and Team, Estonian Biobank Research},
language = {eng},
isbn = {2158-3188},
doi = {10.1038/s41398-022-02196-2},
publisher = {Springer Nature Publishing Group},
year = {2022},
abstract = {{Despite advances in identifying the genetic basis of psychiatric and neurological disorders, fundamental questions about their evolutionary origins remain elusive. Here, introgressed variants from archaic humans such as Neandertals can serve as an intriguing research paradigm. We compared the number of associations for Neandertal variants to the number of associations of frequency-matched non-archaic variants with regard to human CNS disorders (neurological and psychiatric), nervous system drug prescriptions (as a proxy for disease), and related, non-disease phenotypes in the UK biobank (UKBB). While no enrichment for Neandertal genetic variants were observed in the UKBB for psychiatric or neurological disease categories, we found significant associations with certain behavioral phenotypes including pain, chronotype/sleep, smoking and alcohol consumption. In some instances, the enrichment signal was driven by Neandertal variants that represented the strongest association genome-wide. SNPs within a Neandertal haplotype that was associated with smoking in the UKBB could be replicated in four independent genomics datasets.}},
journal = {{Translational Psychiatry}},
volume = {12},
eid = {433},
}