% pubman genre = article
@article{item_3526284,
title = {{Apolipoprotein-$\varepsilon$4 is associated with higher fecundity in a natural fertility population}},
author = {Trumble, Benjamin C. and Charifson, Mia and Kraft, Tom and Garcia, Angela R. and Cummings, Daniel K. and Hooper, Paul and Lea, Amanda J. and Eid Rodriguez, Daniel and Koebele, Stephanie V. and Buetow, Kenneth and Beheim, Bret and Minocher, Riana and Gutierrez, Maguin and Thomas, Gregory S. and Gatz, Margaret and Stieglitz, Jonathan and Finch, Caleb E. and Kaplan, Hillard and Gurven, Michael},
language = {eng},
issn = {23752548},
doi = {10.1126/sciadv.ade9797},
publisher = {American Association for the Advancement of Science},
year = {2023},
abstract = {{In many populations, the apolipoprotein-$\varepsilon$4 (APOE-$\varepsilon$4) allele increases the risk for several chronic diseases of aging, including dementia and cardiovascular disease; despite these harmful effects at later ages, the APOE-$\varepsilon$4 allele remains prevalent. We assess the impact of APOE-$\varepsilon$4 on fertility and its proximate determinants (age at first reproduction, interbirth interval) among the Tsimane, a natural fertility population of forager-horticulturalists. Among 795 women aged 13 to 90 (20{\textpercent} APOE-$\varepsilon$4 carriers), those with at least one APOE-$\varepsilon$4 allele had 0.3 to 0.5 more children than ($\varepsilon$3/$\varepsilon$3) homozygotes, while those with two APOE-$\varepsilon$4 alleles gave birth to 1.4 to 2.1 more children. APOE-$\varepsilon$4 carriers achieve higher fertility by beginning reproduction 0.8 years earlier and having a 0.23-year shorter interbirth interval. Our findings add to a growing body of literature suggesting a need for studies of populations living in ancestrally relevant environments to assess how alleles that are deleterious in sedentary urban environments may have been maintained by selection throughout human evolutionary history. Among natural fertility forager-farmers, women with the APOE-?4 allele have more children, and the effect is dose dependent.}},
journal = {{Science Advances}},
volume = {9},
number = {32},
}