% pubman genre = article @article{item_3549009, title = {{The effects of lifestyle change on indicators of cardiometabolic health in semi-nomadic pastoralists}}, author = {Swanson, Zane S. and Bethancourt, Hilary and Nzunza, Rosemary and Ndiema, Emmanuel and Braun, David R. and Rosinger, Asher Y. and Pontzer, Herman}, language = {eng}, isbn = {2050-6201}, doi = {10.1093/emph/eoad030}, year = {2023}, date = {2023-01-01}, abstract = {{Background and objectives Non-communicable disease risk and the epidemic of cardiometabolic diseases continue to grow across the expanding industrialized world. Probing the relationships between evolved human physiology and modern socioecological conditions is central to understanding this health crisis. Therefore, we investigated the relationships between increased market access, shifting subsistence patterns and cardiometabolic health indicators within Daasanach semi-nomadic pastoralists who vary in their engagement in traditional lifestyle and emerging market behaviors.Methodology We conducted cross-sectional socioecological, demographic and lifestyle stressor surveys along with health, biomarker and nutrition examinations among 225 (51.6{\textpercent} female) Daasanach adults in 2019-2020. We used linear mixed-effects models to test how differing levels of engagement in market integration and traditional subsistence activities related to blood pressure (BP), body composition and blood chemistry.Results We found that systolic and diastolic BP, as well as the probability of having high BP (hypertension), were negatively associated with distance to market, a proxy for market integration. Additionally, body composition varied significantly by socioeconomic status (SES), with significant positive associations between BMI and body fat and higher SES among adults.Conclusions and implications While evidence for evolutionary mismatch and health variation have been found across a number of populations affected by an urban/rural divide, these results demonstrate the effects of market integration and sedentarization on cardiometabolic health associated with the early stages of lifestyle changes. Our findings provide evidence for the changes in health when small-scale populations begin the processes of sedentarization and market integration that result from myriad market pressures.{\textless}br{\textgreater} Being settled is associated with poor cardiometabolic health indicators among Daasanach pastoralists in northern Kenya. This study demonstrates the effects of lifestyle change on health among adults in a population at the beginning stages of market integration and reduced reliance on traditional subsistence strategies, providing clinically and evolutionarily relevant insight for global health.}}, journal = {{Evolution, Medicine , {\&} Public Health }}, volume = {11}, number = {1}, pages = {318--331}, }