% pubman genre = article @article{item_3559077, title = {{Accurate detection of identity-by-descent segments in human ancient DNA}}, author = {Ringbauer, Harald and Huang, Yilei and Akbari, Ali and Mallick, Swapan and Olalde, I{\~n}igo and Patterson, Nick and Reich, David}, language = {eng}, isbn = {1546-1718}, doi = {10.1038/s41588-023-01582-w}, year = {2024}, date = {2024-01}, abstract = {{Long DNA segments shared between two individuals, known as identity-by-descent (IBD), reveal recent genealogical connections. Here we introduce ancIBD, a method for identifying IBD segments in ancient human DNA (aDNA) using a hidden Markov model and imputed genotype probabilities. We demonstrate that ancIBD accurately identifies IBD segments {\textgreater}8 cM for aDNA data with an average depth of {\textgreater}0.25$\times$ for whole-genome sequencing or {\textgreater}1$\times$ for 1240k single nucleotide polymorphism capture data. Applying ancIBD to 4,248 ancient Eurasian individuals, we identify relatives up to the sixth degree and genealogical connections between archaeological groups. Notably, we reveal long IBD sharing between Corded Ware and Yamnaya groups, indicating that the Yamnaya herders of the Pontic-Caspian Steppe and the Steppe-related ancestry in various European Corded Ware groups share substantial co-ancestry within only a few hundred years. These results show that detecting IBD segments can generate powerful insights into the growing aDNA record, both on a small scale relevant to life stories and on a large scale relevant to major cultural-historical events.}}, journal = {{Nature Genetics}}, volume = {56}, number = {1}, pages = {143--151}, }