% pubman genre = article
@article{item_3584025,
title = {{Origin and dispersal history of Hepatitis B virus in Eastern Eurasia}},
author = {Sun, Bing and Andrades Valtue{\~n}a, Aida and Kocher, Arthur and Gao, Shizhu and Li, Chunxiang and Fu, Shuang and Zhang, Fan and Ma, Pengcheng and Yang, Xuan and Qiu, Yulan and Zhang, Quanchao and Ma, Jian and Chen, Shan and Xiao, Xiaoming and Damchaabadgar, Sodnomjamts and Li, Fajun and Kovalev, Alexey and Hu, Chunbai and Chen, Xianglong and Wang, Lixin and Li, Wenying and Zhou, Yawei and Zhu, Hong and Krause, Johannes and Herbig, Alexander and Cui, Yinqiu},
language = {eng},
issn = {2041-1723},
doi = {10.1038/s41467-024-47358-6},
publisher = {Nature Publishing Group},
address = {London},
year = {2024},
date = {2024-04},
abstract = {{Hepatitis B virus is a globally distributed pathogen and the history of HBV infection in humans predates 10000 years. However, long-term evolutionary history of HBV in Eastern Eurasia remains elusive. We present 34 ancient HBV genomes dating between approximately 5000 to 400 years ago sourced from 17 sites across Eastern Eurasia. Ten sequences have full coverage, and only two sequences have less than 50{\textpercent} coverage. Our results suggest a potential origin of genotypes B and D in Eastern Asia. We observed a higher level of HBV diversity within Eastern Eurasia compared to Western Eurasia between 5000 and 3000 years ago, characterized by the presence of five different genotypes (A, B, C, D, WENBA), underscoring the significance of human migrations and interactions in the spread of HBV. Our results suggest the possibility of a transition from non-recombinant subgenotypes (B1, B5) to recombinant subgenotypes (B2 - B4). This suggests a shift in epidemiological dynamics within Eastern Eurasia over time. Here, our study elucidates the regional origins of prevalent genotypes and shifts in viral subgenotypes over centuries.}},
journal = {{Nature Communications}},
volume = {15},
eid = {2951},
}