% pubman genre = article
@article{item_3591323,
title = {{Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity}},
author = {Brunet-Ratnasingham, Elsa and Morin, Sacha and Randolph, Haley E. and Labrecque, Marjorie and B{\'e}lair, Justin and Lima-Barbosa, Rapha{\"e}l and Pagliuzza, Am{\'e}lie and Marchitto, Lorie and Hultstr{\"o}m, Michael and Niessl, Julia and Cloutier, Rose and Sreng Flores, Alina M. and Brassard, Nathalie and Benlarbi, Mehdi and Pr{\'e}vost, J{\'e}r{\'e}mie and Ding, Shilei and Anand, Sai Priya and Sannier, G{\'e}r{\'e}my and Marks, Amanda and W{\aa}gs{\"a}ter, Dick and Bareke, Eric and Zeberg, Hugo and Lipcsey, Miklos and Frithiof, Robert and Larsson, Anders and Zhou, Sirui and Nakanishi, Tomoko and Morrison, David and Vezina, Dani and Bourassa, Catherine and Gendron-Lepage, Gabrielle and Medjahed, Halima and Point, Floriane and Richard, Jonathan and Larochelle, Catherine and Prat, Alexandre and Cunningham, Janet L. and Arbour, Nathalie and Durand, Madeleine and Richards, J. Brent and Moon, Kevin and Chomont, Nicolas and Finzi, Andr{\'e}s and T{\'e}treault, Martine and Barreiro, Luis and Wolf, Guy and Kaufmann, Daniel E.},
language = {eng},
issn = {2041-1723},
doi = {10.1038/s41467-024-48556-y},
year = {2024},
abstract = {{Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized patients with COVID-19. Integrated analysis using k-means reveals four patient clusters in a discovery cohort: mechanically ventilated critically-ill cases are subdivided into good prognosis and high-fatality clusters (reproduced in a validation cohort), while non-critical survivors segregate into high and low early antibody responders. Only the high-fatality cluster is enriched for transcriptomic signatures associated with COVID-19 severity, and each cluster has distinct RBD-specific antibody elicitation kinetics. Both critical and non-critical clusters with delayed antibody responses exhibit sustained IFN signatures, which negatively correlate with contemporaneous RBD-specific IgG levels and absolute SARS-CoV-2-specific B and CD4+ T cell frequencies. These data suggest that the {\textquotedblleft}Interferon paradox{\textquotedblright} previously described in murine LCMV models is operative in COVID-19, with excessive IFN signaling delaying development of adaptive virus-specific immunity. {\copyright} The Author(s) 2024.}},
journal = {{Nature Communications}},
volume = {15},
eid = {4177},
}