% pubman genre = article
@article{item_3627736,
title = {{An organotypic atlas of human vascular cells}},
author = {Barnett, Sam N. and Cujba, Ana-Maria and Yang, Lu and Maceiras, Ana Raquel and Li, Shuang and Kedlian, Veronika R. and Pett, J. Patrick and Polanski, Krzysztof and Miranda, Antonio M. A. and Xu, Chuan and Cranley, James and Kanemaru, Kazumasa and Lee, Michael and Mach, Lukas and Perera, Shani and Tudor, Catherine and Joseph, Philomeena D. and Pritchard, Sophie and Toscano-Rivalta, Rebecca and Tuong, Zewen K. and Bolt, Liam and Petryszak, Robert and Prete, Martin and Cakir, Batuhan and Huseynov, Alik and Sarropoulos, Ioannis and Chowdhury, Rasheda A. and Elmentaite, Rasa and Madissoon, Elo and Oliver, Amanda J. and Campos, Lia and Brazovskaja, Agnieska and Gomes, Tom{\'a}s and Treutlein, Barbara and Kim, Chang N. and Nowakowski, Tomasz J. and Meyer, Kerstin B. and Randi, Anna M. and Noseda, Michela and Teichmann, Sarah A.},
language = {eng},
issn = {1078-8956},
doi = {10.1038/s41591-024-03376-x},
publisher = {Nature Pub. Co.},
address = {New York, NY},
year = {2024},
date = {2024-12},
abstract = {{The human vascular system, comprising endothelial cells (ECs) and mural cells, covers a vast surface area in the body, providing a critical interface between blood and tissue environments. Functional differences exist across specific vascular beds, but their molecular determinants across tissues remain largely unknown. In this study, we integrated single-cell transcriptomics data from 19 human organs and tissues and defined 42 vascular cell states from approximately 67,000 cells (62 donors), including angiotypic transitional signatures along the arterial endothelial axis from large to small caliber vessels. We also characterized organotypic populations, including splenic littoral and blood{\textendash}brain barrier ECs, thus clarifying the molecular profiles of these important cell states. Interrogating endothelial{\textendash}mural cell molecular crosstalk revealed angiotypic and organotypic communication pathways related to Notch, Wnt, retinoic acid, prostaglandin and cell adhesion signaling. Transcription factor network analysis revealed differential regulation of downstream target genes in tissue-specific modules, such as those of FOXF1 across multiple lung vascular subpopulations. Additionally, we make mechanistic inferences of vascular drug targets within different vascular beds. This open-access resource enhances our understanding of angiodiversity and organotypic molecular signatures in human vascular cells, and has therapeutic implications for vascular diseases across tissues.}},
journal = {{Nature Medicine}},
volume = {30},
number = {12},
pages = {3468--3481},
}