% pubman genre = article
@article{item_3669063,
title = {{Opportunities for single{-}cell sequencing in synthetic biology}},
author = {Wollny, Damian},
language = {eng},
doi = {10.1002/syst.202000016},
publisher = {Wiley-VCH},
address = {Weinheim},
year = {2020},
date = {2020-11},
abstract = {{Single-cell sequencing describes the ability to extract information from a single cell among a heterogeneous mix of cell types by sequencing its DNA or RNA. The development of this technology created tremendous excitement in biology. Akin to gaining higher resolution on a microscope, single-cell sequencing opened our eyes towards previously unknown cellular heterogeneity and the underlying molecular mechanisms. This technology, however, could in principle be applied to any non-living particle capable of carrying nucleotides. This article proposes the application of single-cell sequencing in synthetic biology in order to analyze large numbers of artificially-generated or re-engineered synthetic cells simultaneously. The high-throughput nature of this technology provides the opportunity to test multiple hypotheses in parallel and thus accelerate the pace of discovery. Synthetic biology serves as a particularly exciting example of many overlooked non-canonical applications of single-cell sequencing.}},
journal = {{ChemSystemsChem}},
volume = {2},
number = {6},
eid = {e2000016},
}