%0 Journal Article %A Dannemann, Michael %A Prüfer, Kay %A Kelso, Janet %+ The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Genomes, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society %T Functional implications of Neandertal introgression in modern humans : %G eng %U https://hdl.handle.net/11858/00-001M-0000-002D-084D-C %R 10.1186/s13059-017-1181-7 %7 2017-04-03 %D 2017 %8 03.04.2017 %* Review method: peer-reviewed %X Admixture between early modern humans and Neandertals approximately 50,000–60,000 years ago has resulted in 1.5–4% Neandertal ancestry in the genomes of present-day non-Africans. Evidence is accumulating that some of these archaic alleles are advantageous for modern humans, while others are deleterious; however, the major mechanism by which these archaic alleles act has not been fully explored. %K Gene expression regulation, Human evolution, Neandertal introgression, Protein sequence variation %J Genome Biology %V 18 %] 61 %I BioMed Central Ltd. %C London %@ 1465-69061474-760X