%0 Journal Article
%A Camp, J. Gray
%A Treutlein, Barbara
%+ Modern and Archaic Human Cell Biology, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
Single Cell Genomics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Human organomics: A fresh approach to understanding human development using single-cell transcriptomics : 
%G eng
%U https://hdl.handle.net/11858/00-001M-0000-002D-46EF-1
%R 10.1242/dev.150458
%7 2017-05-02
%D 2017
%* Review method: peer-reviewed
%X Skip to Next Section
Innovative methods designed to recapitulate human organogenesis from pluripotent stem cells provide a means to explore human developmental biology. New technologies to sequence and analyze single-cell transcriptomes can deconstruct these ‘organoids’ into constituent parts, and reconstruct lineage trajectories during cell differentiation. In this Spotlight article we summarize the different approaches to performing single-cell transcriptomics on organoids, and discuss the opportunities and challenges of applying these techniques to generate organ-level, mechanistic models of human development and disease. Together, these technologies will move past characterization to the prediction of human developmental and disease-related phenomena.
%J Development
%V 144
%N 9
%& 1584
%P 1584 - 1587
%@ 0950-19911477-9129