%0 Journal Article %A Prüfer, Kay %A Filippo, Cesare de %A Grote, Steffi %A Mafessoni, Fabrizio %A Korlevic, Petra %A Hajdinjak, Mateja %A Vernot, Benjamin %A Skov, Laurits %A Hsieh, Pinghsun %A Peyrégne, Stéphane %A Reher, David %A Hopfe, Charlotte %A Nagel, Sarah %A Maricic, Tomislav %A Fu, Qiaomei %A Theunert, Christoph %A Rogers, Rebekah %A Skoglund, Pontus %A Chintalapati, Manjusha %A Dannemann, Michael %A Nelson, Bradley J. %A Key, Felix M. %A Rudan, Pavao %A Kucan, Željko %A Gušic, Ivan %A Golovanova, Liubov V. %A Doronichev, Vladimir B. %A Patterson, Nick %A Reich, David %A Eichler, Evan E. %A Slatkin, Montgomery %A Schierup, Mikkel H. %A Andrés, Aida M. %A Kelso, Janet %A Meyer, Matthias %A Pääbo, Svante %+ Genomes, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Genetic Diversity and Selection, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Genomes, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Neandertals and more, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Genomes, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society Genetic Diversity and Selection, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Neandertals and more, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Genomes, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Genetic Diversity and Selection, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society The Minerva Research Group for Bioinformatics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Advanced DNA Sequencing Techniques, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society Neandertals and more, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society %T A high-coverage Neandertal genome from Vindija Cave in Croatia : %G eng %U https://hdl.handle.net/11858/00-001M-0000-002E-006B-4 %R 10.1126/science.aao1887 %7 2017-10-05 %D 2017 %8 03.11.2017 %* Review method: peer-reviewed %X To date the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50 thousand years ago from Vindija Cave, Croatia to ~30-fold genomic coverage. She carried 1.6 differences per ten thousand base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10-20% more Neandertal DNA to be identified in present-day humans, including variants involved in LDL cholesterol levels, schizophrenia and other diseases. %J Science %V 358 %N 6363 %& 655 %P 655 - 658 %I American Association for the Advancement of Science %C Washington, D.C. %@ 0036-8075