%0 Journal Article %A Maibach, Vincent %A Vigilant, Linda %+ Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society Molecular Genetics Laboratory, Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society %T Reduced bonobo MHC class I diversity predicts a reduced viral peptide binding ability compared to chimpanzees : %G eng %U https://hdl.handle.net/21.11116/0000-0002-E3B9-D %R 10.1186/s12862-019-1352-0 %7 2019-01-10 %D 2019 %8 10.01.2019 %* Review method: peer-reviewed %X The highly polymorphic genes of the major histocompatibility complex (MHC) class I are involved in defense against viruses and other intracellular pathogens. Although several studies found reduced MHC class I diversity in bonobos in comparison to the closely related chimpanzee, it is unclear if this lower diversity also influences the functional ability of MHC class I molecules in bonobos. Here, we use a bioinformatic approach to analyze the viral peptide binding ability of all published bonobo MHC class I molecules (n =þinspace}58) in comparison to all published chimpanzee MHC class I molecules (n ={þinspace161) for the class I loci A, B, C and A-like. %K Pan paniscus, Pan troglodytes, Great apes, NetMHCpan, Major histocompatibility complex %J BMC Evolutionary Biology %V 19 %] 14 %I Springer %C Berlin %@ 1471-2148